【摘要】 目的:探讨H-FABP与cTnI、CK、Mb、CK-Mb联合检测在急性冠脉综合征患者诊断中的临床价值。方法:采用ELISA法检测81例6h内胸痛发作患者的血清H-FABP水平,采用免疫荧光法测定这些患者血清中的cTnI、CK、Mb、CK-Mb,其中急性心肌梗死(AMI)30例、不稳定型心绞痛(UAP)26例、非心源性胸痛(NCCP)25例,同期选择27例健康体检者为对照组。应用Logistic回归模型绘制ROC曲线并计算曲线下面积(AUC)来评估H-FABP的诊断价值。结果:AMI组的H-FABP水平(73.35±56.73)μg/L最高,UAP组(13.50±5.64)μg/L次之(P<0.01);NCCP组(4.07±3.27)μg/L与对照组(3.42±1.53)μg/L比较差异无统计学意义(P>0.05)。H-FABP诊断AMI敏感性(96.7%)明显优于cTnI诊断敏感性74.5%(P<0.05);H-FABP与cTnI联合检测ROC曲线下面就更高达0.908。结论:H-FABP与cTnI联合检测可为急性冠脉综合征患者的诊断提供依据。更多还原

【Abstract】 Objective:To investigate the clinic value of serum heart-type fatty acid-binding protein and cTnI、 CK、Mb、CK-Mb on prognosis of patients with acute coronary syndrme.Method:The H-FABP level was measured within 6hafter onset of chest pain in 81patients by ELISA methods and cTnI、CK、Mb、CK-Mb by immunofluore- sent assays.With 30cases of acute myocardial infarction(AMI),26cases of unstable angina pectoris(UAP),25 cases of non-cardiac chest pain(NCCP),at the same period 27healthy volunteers were selected as the control group.H-FABP diagnosis value is evaluated by the area under the concentration-time curve of receiver operating characteristic rendered using Logistic regression model.Result:The H-FABP level(73.35±56.73)μg/L in AMI group was highest,and the H-FABP level(13.50±5.64)μg/L in UAP group was higher(P<0.01).There was no statistically significant between NCCP group(4.07±3.27)μg/L and the control group(3.42±1.53)μg/L. The sensitivity of H-FABP on diagnosis of AMI(96.7%)was significantly better than that of cTnI(80%)(P< 0.05),comparison of specific between the two had no significant difference.The area under the concentration-time curve of receiver operating characteristic of H-FABP and cTnI is up to 0.908.Conclusion:The H-FABP and cTnI level could be diagnostic basis for acute coronary syndrme.更多还原