【摘要】 目的探讨不同性别Hb浓度和非酒精性脂肪性肝病(NAFLD)发生风险之间的关系。方法以2012年1月至2012年12月上海市仁济医院健康保健中心年龄≥18岁的体检人群为研究对象,依据男女Hb的不同进行分组,评估各组NAFLD的患病率。结果入组的61 646人中,平均年龄(44±14)岁,男性34 961人,女性26 685人。超声诊断为NAFLD者20 401人,占33.09%。不论在男性组还是女性组,NAFLD患病率随着Hb水平的升高而升高(P<0.001),男性NAFLD的患病率高于女性(44.7%比17.9%,χ2=4 900,P<0.001),在Logistic回归分析中,NAFLD患病率和Hb水平呈现正相关的关系,在男性组,作多变量分析时,第1组作为参照,第2组、第3组、第4组的OR值分别为1.31(95%CI:1.18-1.45)、1.38(95%CI:1.24-1.53)、1.29(95%CI:1.05-1.58),均P<0.05。在女性组,多变量分析时,OR值分别为1.08(95%CI:0.95-1.22)、1.26(95%CI:1.09-1.45)、1.59(95%CI:1.06-2.38),除第2组外,另两组均P<0.05。男性患NAFLD的风险较女性高(OR为3.7,95%CI:3.57-3.85,P<0.001)。结论 Hb水平和NAFLD呈正相关关系,高Hb水平是独立于肥胖和代谢综合征的NAFLD的又一风险因素。男性NAFLD发生风险是女性的3.7倍。更多还原

【Abstract】 Objective To explore the relationship between hemoglobin level and the risk of non-alcoholic fatty liver disease(NAFLD)based on gender.Methods A cross-sectional study of on 61,646 subjects was conducted,which was more than 18 years old and underwent a routine health check-up in the Health Care Center,Renji Hospital,Shanghai Jiao Tong University School of Medicine between 1st January 2012 and 31st December 2012.The incidence of NAFLD was evaluated according to gender and level of hemoglobin.Results Of 61 646 subjects,the mean age was 44 years,and 34 961(56.7%) were men.,and 20 401(33.09%) were diagnosed with NAFLD by ultrasound.The prevalence of NAFLD increased steadily as hemoglobin level increased in both men and women(P<0.001for both).The prevalence of NAFLD was higher in men than that in women(44.7% vs 17.9%,χ2=4 900,P<0.001).The multivariate logistic forward regression showed that hemoglobin level had a positive correlation with the prevalence of NAFLD(For men,OR=1.31, 95%CI=1.18-1.45 in the second quartile;OR=1.38,95%CI=1.24-1.53 in the third quartile;OR=1.29,95%CI= 1.05-1.58 in the fourth quartile vs.control quartile;P<0.05,respectively.For women,OR=1.26,95%CI=1.09- 1.45 in the third quartile;OR=1.59,95%CI=1.06-2.38in the fourth quartile vs.the lowestcontrol quartile;P<0.05 respectively;Pvalue was more than 0.05 in the second quartile vs control quartile).Men had a greater risk of the prevalence of NAFLD(OR=3.7,95%CI=3.57-3.85,P<0.001) than that in women.Conclusion Hemoglobin level has a positive correlationis with the prevalence of NALFD.In addition to obesity and metabolic syndrome,high hemoglobin level is one of independent risk factors for NAFLD.The prevalence of NAFLD in men is 3.7 times higher than that in women.更多还原