【摘要】 目的:研究桃仁乙醇提取物对三氯化铝(AlCl3)致痴呆小鼠空间学习记忆和抗疲劳的作用及机制。方法:采用AlCl3(200 mg.kg-1,ig,40 d)以复制痴呆小鼠模型。以Morris水迷宫、疲劳仪,观察桃仁乙醇提取物(2.8,1.4,0.7 g.kg-1,ig,40 d)对小鼠空间学习记忆和抗疲劳的作用,测定脑组织丙二醛(MDA)含量和乙酰胆碱酯酶(AchE)活性。结果:桃仁乙醇提取物(2.8 g.kg-1)使1 min站台穿越次数明显增加;并提高痴呆小鼠的抗疲劳能力,桃仁乙醇提取物使痴呆小鼠脑组织MDA含量和AchE活性明显降低。结论:桃仁乙醇提取物对痴呆小鼠空间学习记忆有明显的改善作用和抗疲劳能力,其机制可能与降低MDA含量和AchE活性有关。更多还原

【Abstract】 Objective: To Study effect of ethanol extract from Persicae Seman on spatial learning memory and anti-fatigue in dementia mice induced by AlCl3.Method: The mouse dementia model was induced by AlCl3(200 mg.kg-1,ig,40 d).Morris water maze test and the fatigue instrument were used to observe effect of ethanol extract malondial dehyde(MDA) contents and a cetylcholinesterase(AchE) activity in brain tissue were measured.Result: The ethanol extract from Persicae Semen(2.8 g.kg-1) could significantly increase traversing times in 1 min platform.It can could improveanti-fatigue effect,and decrease MDA contents and AchE activity in brain tissue.Conclusion: The ethanol extract from Persicae Semen has improvement effect and anti-fatigue effect on spatial learning memory and anti-fatigue in dementia mice.Its mechanism maybe related to MDA contents and AchE activity.更多还原