【摘要】 目的探讨川崎病(KD)并发冠状动脉病变(CAL)的影响因素。方法对2009—2011年山东省立医院儿科确诊的143例KD患儿临床资料进行回顾性分析,采集性别、年龄、发热持续时间、血红蛋白(Hb)、血细胞沉降率(ESR)、C-反应蛋白(CRP)、白细胞(WBC)、血小板(PLT)、血清白蛋白(Alb)、心肌肌钙蛋白(cTnI)、N末端脑利钠肽前体(NT-proBNP)等共11项临床资料。分为KD并发CAL组27例和无CAL(NCAL)组116例,进行单因素和多因素回归分析。结果单因素分析显示:热程>10d,ESR、PLT、CRP、Alb、cTnI、NT-proBNP与KD并发CAL相关联(P<0.05或P<0.01);多因素Logistic回归分析显示:热程>10d、Alb下降、cTnI升高与KD合并CAL显著独立相关(P<0.05)。结论热程>10d、Alb下降、cTnI升高是KD发生CAL的高危因素。关键词:川崎病;冠状动脉病变;危险因素;Logistic回归分析更多还原

【Abstract】 Objective To explore the risk factors in children with coronary artery lesion (CAL) complication in Kawasaki disease (KD) . Methods Retrospective analyses of the clinical data from 143 children with KD from 2009 to 2011 in Shandong Provincial Hospital were performed in terms of 11 aspects including the fever duration , hemoglobin (Hb), erythrocyte sedimentation rate (ESR), C-reaction protein (CRP), white blood cell count (WBC), blood platelet (PLT), and the patients ’ gender and age. 143 children were divided into two groups according to whether these KD patients were with or without CAL.Both single factor and multivariate logistic regression analyses were performed. Results Single factor analysis showed that fever duration over 10 days , ESR , PLT , CRP , ALB , cTnI and NT-porBNP were risk factors to KD complicated with CAL (P<0.05 or P<0.01) .Multivariate logistic regression analysis showed that a fever duration over 10 days , decrease of ALB and increase of cTnI were significant risk factors to KD complicated with CAL (P<0.05) . Conclusion Fever duration over 10 days , decrease of ALB and increase of cTnI are important risk factors to KD complicated with CAL.更多还原