【摘要】 弓形虫疫苗研制已经历了全虫疫苗、抗原组份疫苗、基因工程亚单位疫苗和核酸疫苗发展阶段,结果表明基因工程多价疫苗具有较大的前景。本文综述了弓形虫多价疫苗的研制中弓形虫抗原基因的筛选方法、表达载体的选择、研制方法及疫苗种类,并介绍了弓形虫多价疫苗的应用和目前存在的问题及解决策略。更多还原

【Abstract】 The development of Toxoplasma gondii vaccine has experienced the whole worm vaccines stage,antigen components vaccine stage,gene engineering subunit vaccine stage,and nucleic acid vaccine stage.The results show that genetic engineering multivalent vaccines have great prospects.In this paper,the preparation of Toxoplasma gondii multivalent vaccines are reviewed,including the method of selecting Toxoplasmaantigen gene,the choice of expression vector,development of the method,and vaccines of the types.Meanwhile,it also reviews the application of Toxoplasma gondii multivalent vaccines and the existing problems and the solving strategy at present.更多还原