【摘要】 目的:探讨氯米帕明合用喹硫平治疗难治性强迫症的临床疗效。方法:研究对象为采用单用氯米帕明治疗12周后仍然未有疗效的患者,将60名难治性强迫症患者分为两组,分别用氯米帕明合用安慰剂、氯米帕明合用喹硫平,进行为期8周的治疗研究。采用强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评定疗效。结果:8周治疗后,氯米帕明合用喹硫平组显效率较高,4周和8周治疗后,Y-BOCS评分、HAMA、HAMD的分数较治疗前均显著下降(P<0.05),而安慰剂添加组评分未有明显变化。结论:氯米帕明合用喹硫平治疗难治性强迫症可以提高疗效。更多还原

【Abstract】 Objective: To discuss efficacy of clomipramine combined with quetiapine in treatment of patients with refractory obsessive- compulsive disorder(OCD). Methods: 60 patients with refractory OCD,who had been treated with clomipramine for 12weeks but still not cured,were selected and randomly divided into clomipramine combined with placebo group and clomipramine combined with quetiapine group,and they were treated for 8 weeks. The efficacy was assessed with Yale- Brown obsessive- compulsive scale(Y- BOCS),Hamilton Anxiety Scale(HAMA) and Hamilton Depression Scale(HAMD). Results: 8 weeks after the treatment,the obvious effective rate of clomipramine combined with quetiapine group was higher; and 4 and 8 weeks after the treatment,the scores of Y- BOCS,HAMA and HAMD all significantly decreased compared with those before the treatment(p<0. 05). However,there were no obvious changes in these scores for clomipramine combined with placebo group. Conclusions: It is suggested that clomipramine combined with quetiapine could improve the efficacy in the treatment of refractory OCD.更多还原