【摘要】 目的探讨组织弥散定量技术中蓝色区域面积百分比(AREA%)对不同功能状态桥本甲状腺炎(HT)的评估价值。方法收集107例经临床确诊的HT患者,根据实验室检查结果分为HT甲亢组、HT甲功正常组、HT甲减组,另选50例健康志愿者作为对照组。所有入选者经常规超声扫查后,采用实时超声弹性成像技术进行组织弥散定量分析,测量感兴趣区域的AREA%,进行组间和组内差异性比较并进一步分析AREA%与HT病程的相关性。结果桥本甲状腺炎患者AREA%为(13.54±6.56)%,对照组AREA%为(3.45±1.41)%,差异有统计学意义(P<0.05);HT甲亢组、HT甲功正常组、HT甲减组的AREA%分别为(7.55±3.91)%、(11.41±3.91)%,(19.22±5.28)%,各组间AREA%有统计学差异(P<0.05)。AREA%与不同功能状态HT的相关系数r=0.851(P=0.001)。结论 HT患者不同甲功时期甲状腺硬度不同,超声弹性成像组织弥散定量分析技术能够较敏感地发现并无创、定量评估这种差异。更多还原

【Abstract】 Objective To investigate the clinical value of quantitative analysis of tissue diffusion in assessing the stiffness of thyroid in patients with Hashimoto thyroiditis. Methods Totally 107 patients who had been diagnosed clinically as Hashimoto thyroiditis were enrolled in the study. According to the results of thyroid function tests, patients were classified into three groups: the hyperthyroidism group, the euthyroidism group and the clinical hypothyroidism group. Fifty healthy volunteers with normal thyroid function were enrolled as a control group. All patients were examined by traditional ultrasound examination and real-time tissue elastography. AREA% in ROI was calculated and then compared among different groups. Relationship between AREA% and the thyroid function of HT were also studied. Results Mean value of AREA% was(13.54±6.56)% in the case group and(3.45±1.41)% in the control group. The difference was significant(P<0.05). In three sub-groups, mean value of AREA% was(7.55±3.91)%,(11.41±3.91)%,(19.22±5.28)%, respectively. There were significant differences found in the comparison between all the sub-groups and the control group(P<0.05). AREA% was positively correlated with the thyroid function of Hashimoto thyroiditis, with a correlation coefficient of 0.851(P<0.001). Conclusion Stiffness of thyroid in patients with HT are different among different functional groups. Elastography could detect these changes sensitively and quantitatively.更多还原