【摘要】 目的通过检测14种食物成分的特异性IgG水平,研究食物不耐受与非酒精性脂肪肝、高脂血症的关系。方法选择2011~2013年青岛市1052名健康体检者,应用酶联免疫法(ELISA)检测血清14种食物特异性IgG抗体,采用SPSS 17.0软件对相关资料进行χ2检验、非条件Logistic回归分析。结果 (1)1052名受检人群中牛奶不耐受(χ2=70.457,P<0.05)、螃蟹不耐受(χ2=49.040,P<0.05)、海虾不耐受(χ2=20.692,P<0.05)与非酒精性脂肪肝有关;牛奶不耐受与高脂血症有关(χ2=24.871,P<0.05)。(2)分别以非酒精性脂肪肝、高脂血症为因变量,年龄、性别、体重指数(BMI)、海鲜和(或)非海鲜类食物不耐受为自变量进行多因素Logistic回归分析,结果显示非酒精性脂肪肝、高脂血症与海鲜、非海鲜类食物均不耐受组及海鲜类食物不耐受、非海鲜类食物耐受组比较,差异有统计学意义,OR值(95%CI)分别为1.361(1.018~2.057)、1.372(1.040~6.071)、16.976(2.519~125.634)、2.674(1.481~37.087)。结论牛奶、螃蟹、海虾不耐受以及BMI与非酒精性脂肪肝有关,其中牛奶不耐受与非酒精性脂肪肝、高血脂均有关,海产品中螃蟹、海虾不耐受与非酒精性脂肪肝有关;海鲜类食物不耐受较非海鲜类食物不耐受更易导致非酒精性脂肪肝、高脂血症。因此,建议据食物不耐受检测结果加强饮食管理,预防非酒精性脂肪肝、高脂血症的发病。更多还原

【Abstract】 Objective To investigate the association between food intolerance and nonalcoholic fatty liver,hyperuricemia.Methods A total of 1052 Qingdao residents were recruited in this study from 2011 to 2013.ELISA was used to test specific allergic IgG antibodies.Chi-square test and Logistic regression were used for data analysis by SPSS 17.0.Results(1) In the 1052 residents,there were significant difference between food intolerance and nonalcoholic fatty liver: milk intolerance and nonalcoholic fatty liver(χ2= 70.457,P < 0.05),Crab intolerance and nonalcoholic fatty liver(χ2= 49.040,P < 0.05); Prawns intolerance and nonalcoholic fatty liver(χ2= 20.692,P < 0.05); There was significant difference between food intolerance and hyperlipidemia: milk intolerance and hyperlipidemia(χ2= 24.871,P < 0.05);(2) In logistic regression analysis,there was significant difference between nonalcoholic fatty liver and sea food intolerance,non sea food intolerance,the odds ratio was 1.361(1.018-2.057); Nonalcoholic fatty liver and sea food intolerance,non sea food intolerance: 1.372(1.040-6.071); Hyperlipidemia and sea food intolerance,non sea food tolerance: 16.976(2.519-125.634); Hyperlipidemia and sea food intolerance,non sea food tolerance: 2.674(1.481-37.087).Conclusion There is correlation between milk,crab,eggs,Prawns intolerance,BMI and nonalcoholic fatty liver,hyperuricemia; The risk of suffering nonalcoholic fatty liver is larger in sea food intolerance than non sea food; Sea food intolerance result in nonalcoholic fatty liver,hyperlipidemia more easily than non sea food.Therefore,food adjustment might be useful in the prevention and treatment of metabolic disease according to the test results the food intolerance.更多还原