【摘要】 目的观察超小剂量肝素微量泵持续120h静脉滴注治疗小儿重症肺炎的疗效。方法选择住院重症肺炎患儿100例,随机分为治疗组及对照组各50例。两组患儿均按重症肺炎常规治疗,治疗组在此基础上加用肝素,每次10μg.kg-1加24mL生理盐水中持续微量泵静脉滴注,qd,连用120h(5d),观察两组患儿疗效并进行比较。结果治疗组显效30例,有效17例,总有效率94%;对照组显效18例,有效8例,总有效率52%,经χ2检验,P<0.01或<0.05,差异有统计学意义。治疗组患儿咳嗽、发绀、肺部罗音消失时间及平均住院时间均明显短于对照组,经t检验,P<0.01,差异有统计学意义。治疗组患儿心率恢复正常时间、肝脏肿大、惊厥及腹胀消失时间均明显短于对照组,经t检验,P<0.01,差异有统计学意义。结论超小剂量肝素微量泵持续120h静脉滴注治疗小儿重症肺炎,对血小板及凝血系统无影响,疗效显著,安全可靠。更多还原

【Abstract】 Objective To observe the clinical curative effect of 120-hour continuous micro-pump intravenous infusion of ultra-low-dose heparin in the treatment of severe pneumonia in children.Methods A total of 100 children with severe pneumonia were randomly divided into the treatment group(n=50) and the control group(n=50).The two groups of children received the conventional treatment,and at the same time,the treatment group was given 10 μg·kg-1 heparin in 24 mL normal saline through micro-pump intravenous infusion once a day for 120 hours(5 days) continuously and then therapeutic efficacy of the two groups was observed and compared.Results In the treatment group,there were 30 cases recovered,17 cases significantly improved,and the total effective rate was 94%,while in the control group,there were 18 cases recovered,8 cases significantly improved,and the total effective rate was 52%.There was a significant difference between the results of the two groups(by x2 test,P<0.01 or 0.05).In the treatment group,time of the disappearance of cough,cyanosis,lung rales and average hospitalization period were obviously shorter than those in the control group,with a significant difference between the results of the two groups(by t test,P<0.01).In the treatment group,the restorative time of the heart rate and the disappearance time of hepatomegaly,convulsions and abdominal distention were obviously shorter than those of the control group,with a significant difference between the results of the two groups(by t test,P<0.01).Conclusion The treatment of severe pneumonia in children through 120-hour continuous micro-pump intravenous infusion of ultra-low-dose heparin had no adverse effect on platelet and coagulation system which was safe and effective.更多还原