【摘要】 目的:观察秋水仙碱不同给药方案治疗痛风急性发作的临床疗效和不良反应。方法:将56例痛风急性发作患者随机均分为高剂量组和低剂量组。高剂量组在患者痛风急性发作12 h内给予首次服用秋水仙碱1.0 mg,以后每隔2 h服用1次,每次0.5mg,直到疼痛缓解为止;在疼痛缓解72 h后再次开始服用,每次0.5 mg,每日2次。低剂量组在患者痛风急性发作12 h内给予秋水仙碱每次0.5 mg,每日3次,饭后服用;疼痛缓解后,改为每次0.5 mg,每日2次。两组患者均连用7 d后停药。比较两组患者临床症状缓解时间、服药后不同时间的关节疼痛评分减少情况、临床疗效及不良反应发生率。结果:两组患者临床症状缓解时间、服药后不同时间的原关节疼痛评分减少情况、临床疗效(高剂量组总有效率为92.9%,低剂量组总有效率为89.3%)比较,差异均无统计学意义(P>0.05);不良反应发生率低剂量组为10.7%,高剂量组为71.4%,两组比较差异有统计学意义(P<0.01)。结论:治疗痛风急性发作低剂量与高剂量秋水仙碱相比疗效相当,但低剂量秋水仙碱组的不良反应发生率明显较低。更多还原

【Abstract】 OBJECTIVE:To observe clinical efficacy and adverse drug reaction of different dosage schemes of colchicine in the treatment of acute attack of gout.METHODS:56 patients with acute attack of gout were randomly divided into high-dose group and low-dose group.High-dose group was given colchicine 1.0 mg within 12 h acute attack of gout for the first time;and they received colchicine 0.5 mg every 2 hours until the pain had relieved;they were given colchicine again 72 h after pain relief,0.5 mg each time,twice a day.Low-dose group was given colchicine 0.5 mg within 12 h acute attack of gout 3 times a day after each meal;and they received colchicine 0.5 mg twice a day after pain relief.2 groups stopped taking medicines after 7d continuous course treatment.Remission time of clinical symptoms,joint pain score reduction at different time after medication,clinical efficacy and the incidence of ADR were compared between 2 groups.RESULTS:Remission time of clinical symptoms,joint pain score reduction at different time after medication,clinical efficacy(total effective rate of high-dose group was 92.9%,and that of low-dose group was 89.3%),there was no statistical significance(P>0.05);the incidence of ADR in low-dose group and high-dose group were 10.7% and 71.4%;there was statistical significance between 2 groups(P<0.01).CONCLUSIONS:Low dose and high dose of colchicine have the same effect on acute attack of gout,but the incidence of ADR has decreased significantly in low-dose group.更多还原