【摘要】 目的评价诱导化疗加同期放化疗综合应用对局部晚期鼻咽癌患者生存率的影响。方法本院1998年1月～1999年12月初治的鼻咽癌患者Ⅲ期143例、ⅣA期94例,其中综合放化疗组164例,单纯根治性放疗组73例,对两组患者短期生存率即完全缓解率、肿瘤局部控制率及生存期进行比较。结果综合放化疗组的完全缓解率、局部控制率以及生存率均优于单纯根治性放疗组(P<0.05)。结论诱导化疗加同步放化疗可提高局部晚期鼻咽癌患者缓解率、肿瘤局部控制率和生存率,是合理、有效的治疗局部晚期鼻咽癌的方法,可在临床治疗中广泛使用。更多还原

【Abstract】 Objective To analyze affect of the inducing chemotherapy plus the concurrent comprehensive application of radiotherapy and chemotherapy on survival rate of nasopharyngeal carcinoma. Methods One hundred and forty-three patients with stage Ⅲ nasopharyngeal carcinoma and 94 patients with ⅣA nasopharyngeal carcinoma treated in our hospital from January 1998 to December 1999 were selected and divided into the comprehensive radiotherapy and chemotherapy group with 164 patients and the simple radical radiotherapy group with 73 patients. The short-term survival rate, namely the complete remission rate, local tumor control rate and survival rate, of the two groups were compared. Results In comprehensive radiotherapy and chemotherapy group the complete remission rate, local tumor control rate and survival rate were significantly higher than the simple radical radiotherapy group (P < 0.05). Conclusion The inducing chemotherapy plus the concurrent comprehensive application of radiotherapy and chemotherapy can improve the remission rate, local tumor control rate and survival rate for patients with locally advanced nasopharyngeal carcinoma, is a reasonable and effective treatment method for the locally advanced nasopharyngeal carcinoma, and can be widely applied in clinical treatment.更多还原