【摘要】 目的了解中国西部地区人类免疫缺陷病毒(HIV)感染者性伴侣对艾滋病暴露前用药(PrEP)的接受意愿调查情况,探讨接受意愿不同的主要影响因素。方法于2009年10月—2010年6月在中国西部的四川省和新疆维吾尔自治区,采用方便抽样方法招募了473名HIV感染者性伴进行PrEP接受意愿调查。结果 473名调查者的PrEP接受意愿平均得分为(4.16±1.23)分,其中57.29%(271/473)明确表示完全能接受,23.04%(109/473)表示也许能接受,4.02%(19/473)表示不太清楚,9.94%(47/473)表示不太能接受,5.71%(27/473)表示完全不能接受;在最近半年里,发生过性行为的占83.51%(395/473),在发生性行为时能坚持每次都使用安全套的占72.66%(287/395),28.54%(135/473)的人现在患有或者曾经患过性病,仅6.77%(32/473)自报曾经使用过毒品,86.05%(407/473)做过HIV病毒检测;对于艾滋病是否会给自己和家人造成威胁,22.84%(107/473)表示完全不担心,63.96%(300/473)表示有一点担心,13.22%(62/473)非常担心;多因素logistic回归分析结果表明,接受PrEP的影响因素为既往性病史和对艾滋病给自己和家人带来威胁的担心程度,有性病史的HIV感染者性伴侣PrEP接受意愿较高,非常担心和有一点担心艾滋病给自己和家人造成威胁的HIV感染者性伴侣PrEP接受意愿均高于不担心者。结论 PrEP在中国西部地区的HIV感染者性伴侣中是可以接受的。更多还原

【Abstract】 Objective To evaluate potential acceptance of pre-exposure prophylaxis(PrEP) among sexual partners of human immunodeficiency virus(HIV)-infected patients in western China,and to investigate demographic characteristics and sexual relationships among the partners with different levels of acceptance.Methods A cross-sectional study with a snowball sampling method was conducted from July 2009 to April 2010.Totally 473 sexual partners of HIV-infected patients,recruited from Sichuan province and Xinjiang Uygur Autonomous Region,completed a self-administered questionnaire about awareness and use intention of PrEP.Results The average score of PrEP use was 4.16±1.23 among the subjects and 57.29%(271/473)of the subjects reported the intention to use PrEP.The multivariable analysis indicated that significant predictors of PrEP use intention were sexually transmitted infection(STI) history and worried about HIV infection of family members.The partners with STI history were more likely to use PrEP(odds ratio=1.758,95%confidence interval :=1.095-2.821).Compared with those not worrying about HIV infection of family member,the subjects very worrying(OR=3.086,95%CI:1.304-7.304),and a little worrying about HIV infection of family member(OR=2.867,95% CI :1.301-6.317) were more likely to use PrEP.Conclusion The majority of sexual partners of HIV-infected patients showed intention to use PrEP.更多还原