【摘要】 目的探讨血清脑源性神经营养因子水平(BDNF)与血管性痴呆(VD)的相关性。方法选择32例VD患者、35例脑梗死患者和35例正常健康对照者,利用酶联免疫吸附法测定外周血清BDNF水平。并对所有观察对象一般临床资料进行比较,寻找VD的危险因素。结果高血压病在3组中相比,均有显著差异(P<0.05);3组血清中BDNF浓度在脑梗死组最高,VD组最低,VD组与脑梗死组有显著性差异、与健康对照组相比无显著性差异。脑梗死组与正常组相比无显著性差异。结论脑梗死患者血清BDNF浓度稍高于与健康对照者,但无明显差异。VD患者血清BDNF水平明显低于脑梗死患者,且具有显著性差异,但与正常组相比无明显差异。提示BDNF可能参与了脑梗死进展为VD的病理生理过程。更多还原

【Abstract】 Objective To explore the association between the serum level of brain derived neurotrophic factor(BDNF) and vascular dementia(VD).Methods 32 patients of VD,35 cerebral infarct patients were selected.35 health examinated people were chosen simultaneously as controls.in.Enzyme-linked immunosorbant assay(ELISA) was used to measure the serum levels of BDNF.Analyze clinical data to search risk factors to vascular dementia.Results Hypertension showed significantly difference among the three groups(P < 0.05).Serum BNDF concentration of three groups in nondemented cerebral infarction group was the highest,while lowest in vascular dementia group,we found that there are significantly difference between VD and CI,but nosignificantly difference between VD and normal control.Conclusion Serum BDNF level of cerebral infarction patients were slightly above normal controls,but no obvious difference was found.VD patients serum levels of BDNF significantly below the CI,and has the significant difference,there was no obvious difference compared with the normal group,BDNF may be involved in the cerebral infarction progress for vascular dementia pathophysiological events.更多还原