【摘要】 [目的]分析血清瘦素(leptin)水平与小细胞肺癌(SCLC)患者临床病理特征的关系,探讨血清leptin水平是否能够作为SCLC独立的风险因素。[方法]应用酶联免疫吸附法检测41例SCLC患者及51名健康人(对照组)的血清leptin表达水平。[结果]SCLC组与对照组血清leptin平均水平分别是(6.45±2.55)ng/ml和(7.05±2.61)ng/ml,两组间差异无统计学意义(P=0.900)。血清leptin水平与SCLC患者的年龄、吸烟状态以及分期、PS评分无相关性(P>0.05),然而与性别、体质指数(BMI)以及SCLC患者体重下降存在相关性(P<0.05)。[结论]血清lep-tin水平并不能作为SCLC独立的风险因素,但其与SCLC患者营养状况以及恶病质存在相关性,可以作为判断肿瘤营养状态的指标之一。更多还原

【Abstract】 Purpose To investigate the relationship between serum leptin and clinicopathologic features in patients with small cell lung cancer(SCLC) . Methods Serum leptin was determined in 41 patients with SCLC and 51 healthy controls with the ELISA method. Results The mean leptin level was (6.45±2.55)ng/ml in patients with SCLC and (7.05±2.61)ng/ml in controls,without significant difference between the two groups. Serum leptin level did not correlate to age,smoking,stages and performance status (P>0.05),but it positively correlated to gender,BMI and weight loss (P<0.05). Conclusion Serum leptin may not be considered as a independent risk factor for SCLC. However,it correlates to nutrition status and cachexia in patients with SCLC. It may be as a marker to evaluate patients’ performance status.更多还原