【摘要】 人乳头瘤病毒16型(HPV16)E5蛋白具有特殊的生物学活性,在宫颈癌发生过程中起重要作用。HPV16E5蛋白具有转化活性,并可增强E6和E7蛋白的致癌活性。E5蛋白的转化活性主要通过上皮生长因子受体(EGFR)信号上调发挥作用。近年来还发现,HPV16E5蛋白是影响免疫系统和炎症通路的关键因子,可能成为宫颈癌治疗的一个靶标。本文就HPV16E5蛋白当前的研究进展进行综述。更多还原

【Abstract】 E5protein of human papillomavirus type 16plays an important role in cervical carcinogenesis.It has a direct transformation function through up-regulation of epidermal growth factor receptor ( EGFR ) pathway , and also contributes to the transformation function of E6protein and E7protein.In recent years , it has been found that HPV16E5protein affects some immunological factors and some key factors in inflammatory pathway.It is a leading therapeutic target for cervical cancer.Current research progress on HPV16 E5protein is reviewed in this paper.更多还原