【摘要】 目的 评价全身MRI在多发性骨髓瘤(multiple myeloma,MM)诊断与治疗效果评价中的应用价值。方法 采用Siemens 3.0T磁共振对47例经病理证实的MM患者进行化疗前全身MRI,并分别于标准方案化疗3月后及6月后复查。对每一位患者全身MRI发现的病灶进行计数统计,采用多因素方差分析比较化疗前、化疗后3月、化疗后6月全身MRI病灶数有无统计学差异。结果 47例MM中,正常型5例,弥漫型7例,局灶型25例,混合型3例,椒盐型7例。对可视病灶的治疗后随访中(正常型除外,共42例),化疗前全身MRI病灶平均数为(113.90±45.71)个,化疗3月后病灶数平均为(28.00士22.49)个,化疗6月后病灶数平均为(10.04±9.02)个。化疗前与化疗后3个月MRI病灶数有显著性差异(P<0.05),化疗后3个月与6个月之间MRI病灶数有显著性差异(P<0.05)。结论 全身MRI对MM具有较好的诊断价值;对评价MM标准化疗方案后的治疗效果有良好的临床应用价值。更多还原

【Abstract】 Objective To investigate the value of whole-body magnetic resonance imaging(WB-MRI) for diagnosis and treatment efficacy evaluation of multiple myeloma(MM).Methods Forty-seven patients with MM verified by histology were recruited.All the patients underwent WB-MRI before chemotherapy and were followed up at 3 and 6 months after standard chemotherapy regimen treatment.The lesions found on WB-MRI of each patient were counted on different time point respectively.The numbers of the lesions found on different time point were compared using multi-way ANOVA statistic analysis.Results Five imaging patterns were identified on WB-MRI,which were smoldering type(5 patients),diffuse type(7 patients),focal type(25 patients),mixed type(3patients),and salt and pepper type(7 patients).There were 42 patients with visible lesions followed up by WB-MRI after chemotherapy.The mean number of lesions was 113.90 ± 45.71 on WB-MRI before chemotherapy and decreased to 28.00 ± 22.49 and10.04±9.02 at the third and sixth month on follow-up WB-MRI.Significant differences were confirmed between either two of the three groups(P<0.05).Conclusion WB-MRI is a valuable tool for MM diagnosis and has an important clinical value for evaluating the treatment efficacy after chemotherapy.更多还原