【摘要】 目的 探讨延安市脑卒中高危人群血脂、血糖水平与颈动脉斑块发生的相关性。方法 按脑卒中诊断标准,从整群抽样调查中纳入脑卒中高危人群807例,血糖(GLU)采用己糖激酶法;三酰甘油(TG)、总胆固醇(TC)采用循环酶速率法;高密度脂蛋白胆固醇(HDL-C)采用选择性抑制法;低密度脂蛋白胆固醇(LDL-C)采用选择性清除法;载脂蛋白A(APO-A)、载脂蛋白B(APO-B)采用免疫比浊法。检测其水平并与健康对照组748例进行比较,同时进行超声检查,观察颈动脉斑块,分析其相关性。结果 脑卒中高危人群与健康对照组血浆GLU,TG,TC,LDL-C和APO-B差异有统计学意义(P<0.05),HDL-C和APO-A差异无统计学意义(P>0.05);观察组中40~49岁血浆TG,TC,LDL-C和APO-B水平男性高于女性,50岁以后其水平女性高于男性;观察组血浆TG,TC,LDL-C和APO-B水平有斑块高于无斑块,差异有统计学意义(P<0.05)。结论 脑卒中高危人群血浆GLU,TG,TC,LDL-C和APO-B水平和斑块均与疾病有密切的关系,是引起疾病的危险因素,监测血脂、血糖水平及颈动脉斑块对脑卒中高危人群具有重要的意义。更多还原

【Abstract】 Objective To investigate the correlation between lipid,blood glucose and carotid artery plaque in high-risk populations of stroke in Yan’an city.Methods Chose 807 cases of high-risk populations of stroke from the overall sample survey,according to the diagnostic criteria of stroke.Compared with healthy control group,blood glucose(GLU),triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),apolipoprotein A(APOA),apolipoprotein B(APO-B)level of these 807 cases were detected with different methods,at the same time carotid artery plaque of cases were detected by ultrasound examination,and the data was statistically analyzed for its correlation.Results There were significant difference of plasma GLU,TG,TC,LDL-C and APO-B between the high risk population of stroke and healthy control group(P<0.05),no significant differences of HDL-C and APO-A existed(P>0.05).In 40~49 age,the level of TG,TC,LDL and plasma APO-B of male group was higher than that of the female,more than 50 years old.It showed the opposite trend among these four indexes between females and males.In observation group,plasma TG,TC,LDLC and APO-B levels from cases with carotid artery plaque were significant higher than those without plaque(P<0.05).Conclusion Levels of plasma GLU,TG,TC,LDL-C and APO-B and plaque of high risk population were closely associated with the disease of stroke,which were risk factors of stroke.Monitoring of blood lipid TG,TC,LDL-C,APO-B,GLU and plaque has vital clinical significance for the high risk population of stroke.更多还原