【摘要】 miRNAs是一类内源性的、非编码蛋白的、长度约为21~23碱基的单链RNA.它们是生物体中一类重要的调控因子,广泛参与多种生物学活动,包括细胞增殖分化和凋亡、个体发育和肿瘤发生等.miR15a通过与其靶基因mRNA的3′UTR互补结合而调控靶蛋白的表达.通过对人源性miR15a靶蛋白依赖性的功能研究进展予以综述,以期对miR15a功能和相对应的生物学机制的进一步研究提供基础.更多还原

【Abstract】 miRNAs are a set of endogenous single-strand RNAs, which are non-protein-coding and about 21to 23 nt in length. As a kind of vital modulators in organism, they participate in many biological activities,including cell proliferation, differentiation, apoptosis, ontogenesis, tumorigenesis and so on. miR15a modulates the expression pattern of target genes through complementary binding to their 3′ UTR. It is the review that focuses on targeting protein-dependent functional research process of hsa-miR15a and wishes to provide a basis for further studies on the functions and the regulated mechanisms of miR15a.更多还原