【摘要】 目的评价高危型HPV-DNA和薄层液基细胞学检查（TCT）在绝经后妇女宫颈癌筛查中的应用价值。方法随机选择南通市妇幼保健院参加宫颈普查的绝经后妇女346例,同时进行高危型HPV-DNA和TCT检查,发现阳性者即进行病理学活检。结果 HPV-DNA和TCT两种筛查方法的灵敏度比较,差异无统计学意义（P>0.05）。TCT及HPV-DNA两种筛查方法的阳性预测值分别为19.05%和44.64%,统计学上有显著差异(x²值分别为12.91^AB和12.17^AC,P<0.05),与TCT联合HPV筛查的双阳性结果比较,单独HPV筛查的阳性预测值差异无统计学意义（P>0.05）。以病理诊断结果为金标准,ASCUS、LSIL、HSIL、SCC阳性符合率分别为5.56%,27.03%,40.00%,85.71%。结论单一高危型HPV-DNA检测可以作为绝经后妇女宫颈癌筛查的首选方法 。更多还原

【Abstract】 Objective To evaluate the application value of high-risk HPV-DNA and thinprep cytology lest（TCT） in cervical cancer screening among postmenopausal women.Methods Total 346 postmenopausal women receiving common cervical screening in Nantong Maternity and Child Health Hospital were randomly selected to perform high-risk HPV-DNA and TCT check.The cases with positive results received pathological biopsy.Results The difference in sensitivity of HPV-DNA and TCT was not statistically significant（P >0.05）.The positive prediction values of TCT and HPV-DNA were 19.05%and 44.64%,respectively,and the difference was statistically significant(x² value was 12.91^AB and 12.17^AC,respectively,both P<0.05).There was no significant difference between the double positive value of TCT combined with HPV and the positive predictive value of single HPV（P > 0.05）.Taking pathological diagnosis as gold standard,the positive coincidence rate of ASCUS,LSIL,HSIL and SCC was 5.56%,27.03%,40.00%and 85.71%,respectively.Conclusion The single high-risk HPV-DNA test can be used as the preferred method of cervical cancer screening among postmenopausal women.更多还原