【摘要】 目的评价2010-2011年度季节性流行性感冒疫苗对儿童的保护效果。方法选择2010-2011年度实验室确诊流感病例为病例组,在广州市12个区(县级市)采用整群抽样的方法选取子队列,对子队列随访1年无流感样症状的儿童组成子队列组,进行病例-队列研究。利用广州市免疫规划信息管理系统采集流感疫苗接种信息,采用COX比例风险模型分析。结果广州市有308例和774例儿童分别纳入病例组与子队列组,流感疫苗接种率分别为16.9%和36.0%。6～59月龄组、6～23月龄组和24～59月龄组免疫的保护效果分别为61.9%(95%CI:48.5,71.8)、59.3%(95%CI:39.2,72.7)、66.2%(95%CI:46.0,78.8),免疫和完全免疫的保护效果均在55%以上,各年龄组完全免疫的保护效果优于部分免疫(Wald=12.042,P=0.001),但6～23月龄和24～59月龄组间的保护效果差异无统计学意义(Wald=3.784,P=0.052)。结论 2010-2011年度流感疫苗对6～59月龄的儿童具有一定的保护效果,完全免疫的保护效果优于部分免疫,建议儿童全程接种流感疫苗。更多还原

【Abstract】 Objective To access the protection of the children against influenza after the licensure of influenza vaccine in 2010-2011. Methods Influenza cases confirmed by laboratory in 2010-2011 were enrolled as the case group. Subset group was selected in Guangzhou with cluster sampling and followed up for a year. Case-cohort study was conducted between these two groups. Influenza vaccination records were obtained from Children Expanded Programmed Immunization Administrative Computer System and analyzed by COX proportional hazards model analysis. Results In Guangzhou, case group and subset group consist of 308 and 774 children, respectively. The influenza vaccination rate was 16.9% in the case group compared to 36.0% in the subset group. Vaccination and full vaccination provided over 55% protection of children aged 6 to 59 months. Protection by full vaccination was better than by partial vaccination. However, vaccine effectiveness did not differ from children aged 6 to 23 months and 24 to 59 months. Conclusion The influenza vaccine had protection effect among children aged 6 to 59 months. The protection of full vaccination was higher than that of partial vaccination. Full vaccination should be encouraged in children.更多还原