【摘要】 目的:采用X线衰减校正提高前瞻性、多中心研究中99mTc-3PRGD2肺癌SPECT图像定量分析的精确性。方法:经病理确诊的肺癌患者27例,其中肺腺癌23例、鳞癌4例。患者静脉注射99mTc-3PRGD2后40分钟顺序进行全身和局部断层扫描。采用迭代图像重建方法,对获得的99mTc-3PRGD2SPECT图像进行X线衰减校正(CTAC)和非衰减校正重建(NAC)。测量CTAC和NAC病灶所在层面的总计数,感兴趣区域(ROI)病灶的总计数、最大计数和平均计数。分别以病灶ROI内最大计数的38%、42%和48%作为阈值测量CTAC和NAC图像病灶最大长径。结果:经过CTAC后病灶所在层面总计数增加2.09倍,ROI区域病灶的总计数增加3.32倍,病灶最大计数和平均计数与本底比值分别提高了65.9%和70.3%。以病灶ROI最大计数42%作为阈值,CTAC后的病灶最大长径为(5.65±2.77)cm,与CT测量结果一致。结论:采用X线衰减校正是提高99mTc-3PRGD2定量分析的有效方法。更多还原

【Abstract】 Objective: Using X-ray attenuation correction to improve a prospective,multicenter study of 99mTc-3PRGD2 SPECT image quantitative analysis precise in lung patients.Methods: 27 patients,adenocarcinoma of 23 cases and squamous cell carcinoma of 4 cases,diagnosed by pathology.Images of whole body scan and local tomography were obtained after 99mTc-3PRGD2 injection of 40 minutes intravenously.Iterative image reconstruction method was used to obtain the X-ray attenuation correction(CTAC) and no attenuation correction reconstruction(NAC) on the basis of 99mTc-3PRGD2 SPECT images.Total count of the lesions slice,total count,maximum and average count of the region of interest(ROI) were extracted individually from the slices of CTAC and NAC frames.The maximum count 38%,42% and 48% within ROI were chosed as the threshold to measure the diameter length of CTAC and NAC image focus.Results: The results showed that after CTAC,the total count,of the focus slice was increased 2.09 times,the total count of the ROI was increased 3.32 times,maximum and mean counts and the background ratio were increased by 65.9% and 70.3%,individually.With the maximum count 42% of the lesion ROI as the threshold,the lesions maximum size was of(5.65±2.77) cm after CTAC,which is coincidence with CT measurement results.Conclusion: Using X-ray attenuation correction helps to improve 99mTc-3PRGD2 quantitative analysis.更多还原