【摘要】 目的根据WHO(2008版)造血和淋巴肿瘤分类标准,探讨青岛地区淋巴瘤的病理类型及分布特点。方法收集2008年8月～2011年8月青岛大学医学院附属医院诊治664例淋巴瘤,复习其临床资料、HE及免疫组化切片。按WHO(2008版)分类新标准进行病理诊断及分类。结果 664例淋巴瘤中,非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)621例(93.52%),霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)43例(6.48%)。NHL中B细胞淋巴瘤485例(78.10%),T和NK细胞淋巴瘤136例(21.90%)。NHL中,发病构成比居前5位分别为弥漫性大B细胞淋巴瘤-非特殊类型(diffuse large B-cell lym-phoma-unspecified,DLBCL-NOS)277例(44.61%)、黏膜相关淋巴组织结外边缘区淋巴瘤(extranodal marginal zone B-cell lym-phoma of mucosa-associated lymphoid tissue type,MALT)48例(7.73%)、结外NK/T细胞淋巴瘤45例(7.25%)、外周T细胞淋巴瘤-非特殊类型(peripheral T-cell lymphoma-unspecified,PTCL-NOS)33例(5.31%)、慢性淋巴细胞性白血病/小淋巴细胞淋巴瘤(chronic lymphocytic leukemia/small lymphocytic lymphoma,CLL/SLL)32例(5.15%)。HL中以结节硬化型经典型霍奇金淋巴瘤(nodular sclerosis classical Hodgkin’s lymphoma,NSCHL)为多(18例,41.86%)。NHL和HL患者中,男女比例为1.52∶1,平均年龄53岁(2～95岁)。NHL(115例,18.52%)和HL(26例,60.47%)起病部位均以颈部淋巴结为多。结论664例淋巴瘤中,NHL发病远多于HL,NHL中以DLBCL-NOS多见,HL中以NSCHL多见。大部分淋巴瘤类型以男性发病为多,起病部位以颈部淋巴结为多。更多还原

【Abstract】 Purpose To study the pathologic types and characteristics of lymphoma based on the Word Health Organization classification of tumors of hematopoietic and lymphoid tissues(2008) in Qingdao area.Methods Clinical data of lymphoma from August 2008 to August 2011 in the affiliated hospital of Qingdao University Medical College were collected and reviewed,including morphological,immunological and clinical characteristics.According to the new WHO classification all the cases were reappraised.Results Of the 664 cases,621 cases(93.52%)were non-Hodgkin’s lymphoma(NHL) and 43 cases(6.48%) were Hodgkin’s lymphoma(HL).Among NHL cases,78.10% were B-cell neoplasms and 21.90% were T/NK-cell neoplasms.The commonest subtypes were diffuse large B-cell lymphoma,unspecified(DLBCL-NOS,44.61%),extranodal marginal zone B-cell lymphoma of MALT type(MALT,7.73%),extranodal NK/T-cell lymphoma(7.25%),peripheral T-cell lymphoma,unspecified(PTCL-NOS,5.31%),and chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL,5.15%).Nodular sclerosis classical Hodgkin’s lymphoma(NSCHL) was the commonest pathological type of Hodgkin’s lymphoma.The ratio of male to female was 1.52 ∶ 1.The mean age at presentation was 53 years(range 2~95 years).The lymph nodes of the cervical region were most commonly involved.Conclusion Of the 664 cases of lymphoma,DLBCL is the commonest subtype of NHL,and NSCHL is the commonest subtype of HL.Most subtypes show a male predominance with most commonly affected in cervical lymphnodes.更多还原