Relationship between polymorphism of angiotensin-converting enzyme 2 gene and the risk factor of essential hypertension with complicated stroke

【摘要】 Background Essential hypertension (EH) is considered to be one of the most important risk factor of ischemic stroke. Studies about risk factors in the patients are meaningful in early forecast and effective prevention of the onset of stroke. Renin-angiotensin-aldosterone system plays an important role in the regulation of blood pressure and the development of stroke, while recent studies have found that the angiotensin-converting enzyme 2 (ACE2) may be a reversal agent for the development and progression of ischemic stroke. Methods The ACE2 gene was measured in 139 EH patients with ischemic stroke using polymerase chain reaction (PCR) and restriction fragment length polymorphism (PCR-RFLP) tests. Detailed and complete clinical and biochemical data were collected, including pulse pressure, hsCRP, IMT, HDL-C and uric acid levels. Study the correlation between angiotensin-converting enzyme 2 gene and the risk factor for onset of ischemic stroke in EH patients. Results Pulse pressure, hsCRP, IMT and uric acid levels had a positive correlation with on- set of ischemic stroke in EH patients. Among male patients , pulse pressure, hsCRP, IMT and HDL-C were higher in patients carrying A allele than B allele (P < 0.05). While these factors were different in female pa- tients carrying different genotypes in which AA allele were highest. Patients with various genotypes showed different uric acid levels but showed no significant difference. Conclusion Among EH patients with complicated ischemic stroke, those carrying the A / AA allele show high level of risk factors and is likely to have the susceptibility of recurrence of stroke.更多还原

【Abstract】 Background Essential hypertension (EH) is considered to be one of the most important risk factor of ischemic stroke. Studies about risk factors in the patients are meaningful in early forecast and effective prevention of the onset of stroke. Renin-angiotensin-aldosterone system plays an important role in the regulation of blood pressure and the development of stroke, while recent studies have found that the angiotensin-converting enzyme 2 (ACE2) may be a reversal agent for the development and progression of ischemic stroke. Methods The ACE2 gene was measured in 139 EH patients with ischemic stroke using polymerase chain reaction (PCR) and restriction fragment length polymorphism (PCR-RFLP) tests. Detailed and complete clinical and biochemical data were collected, including pulse pressure, hsCRP, IMT, HDL-C and uric acid levels. Study the correlation between angiotensin-converting enzyme 2 gene and the risk factor for onset of ischemic stroke in EH patients. Results Pulse pressure, hsCRP, IMT and uric acid levels had a positive correlation with on- set of ischemic stroke in EH patients. Among male patients , pulse pressure, hsCRP, IMT and HDL-C were higher in patients carrying A allele than B allele (P < 0.05). While these factors were different in female pa- tients carrying different genotypes in which AA allele were highest. Patients with various genotypes showed different uric acid levels but showed no significant difference. Conclusion Among EH patients with complicated ischemic stroke, those carrying the A / AA allele show high level of risk factors and is likely to have the susceptibility of recurrence of stroke.更多还原