【摘要】 目的 探讨血小板分布宽度及平均血小板体积在急性冠脉综合征(ACS)患者中的变化及临床价值。方法选择ACS患者239例,分为急性心肌梗死组(AMI组)及不稳定性心绞痛组(UA组),选择有胸痛表现但经冠状动脉(简称冠脉)造影证实无缺血性心脏病的患者65例作为对照组。所有入选者术前空腹采血测定血小板计数(PLT)、血小板分布宽度(PDW)及平均血小板体积(MPV)并行冠状动脉造影,ACS患者计算冠脉病变支数并作GRACE评分。结果 ACS患者各组MPV及PDW均高于对照组(P<0.05),AMI组MPV及PDW高于UA组(P<0.05)。随着冠脉病变支数及GRACE危险评分增加,MPV及PDW也进一步增加(P<0.05),且MPV及PDW与冠脉病变支数(分别为r=0.566,P<0.05及r=0.351,P<0.05)及GRACE危险评分呈正相关(分别为r=0.775,P<0.05及r=0.571,P<0.05)。MPV与PDW间呈正相关(r=0.47,P<0.05)。结论 ACS患者的PDW及MPV明显增加,而且与急性冠脉综合征患者冠脉病变严重程度相关。更多还原

【Abstract】 Objectives To investigate the clinical value of platelet distribution width and mean platelet volume in patients with acute coronary syndrome(ACS).Methods 239 ACS patients were selected and divided into acute myocardial infarction(AMI) group and unstable angina pectoris(UA) group.65 chest pain patients,without demonstrated ischemic heart disease were selected as control group.Platelet count,platelet distribution width and mean platelet volume were measured before coronary arteriography.The numbers of stenosed coronary artery and GRACE scores for patients with ACS were calculated.Results Compared with control group,the levels of MPV and PDW in ACS patients were significantly higher(P<0.05).The levels of MPV and PDW in AMI group were significantly higher than UA group(P<0.05).With the increase of numbers of stenosed coronary artery and GRACE scores,MPV and PDW level also to increase(P<0.05).The levels of MPV and PDW positively correlated with numbers of stenosed coronary artery(r=0.566,P<0.05 and r=0.351,P<0.05),and GRACE scores(r=0.775,P<0.05 and r=0.571,P<0.05),the level of MPV positively correlated with the level of PDW in ACS patients(r=0.47,P<0.05).Conclusions PDW and MPV elevate significantly,and positively correlate with the severity of diseased coronary artery in ACS patients.更多还原