【摘要】 目的:分析14例毛囊黏蛋白病患者的临床和组织病理表现。方法:对14例毛囊黏蛋白病患者临床资料进行回顾性分析,包括临床、组织病理、误诊及治疗情况。结果:该病多见于中青年男性,皮损好发于头部;14例患者均有毛囊周围细胞浸润和黏蛋白沉积(占100%);对羟氯喹的治疗效果均不好;14例中误诊为8例(占57%)。12例患者为慢性良性型,2例属于恶性型。结论:该病皮损主要分布头部,基本皮疹为浸润的斑块和结节。皮损组织病理检查显示毛囊及其周围有黏蛋白聚积,阿新蓝染色阳性提示诊断毛囊黏蛋白病的线索。更多还原

【Abstract】 Objective:To analyze the clinical and histopathological features of follicular mucinosis.Methods:The clinical and histopathological data of 14 cases of follicular mucinosis diagnosed and treated in our hospital was retrospectively analyzed. Results:They were all male patients,with the age from eleven year-old to seventy year-old(thirty-four year-old in average).The skin lesions were mainly distributed on the head,presented as nodules or plaques.Histopathological examination revealed perifollicular deposition of mucin and(lymphocyte cell) infiltration in all the 14 cases(100%),with positive Alcianblue staining.Misdiagnosis occurred in 8 cases(accounting for 57%),which were corrected according to(histopathological examination). Among them,12 cases were confirmed as chronic benign type and the other two cases diagnosed as malignant type.The response to hydroxychloroquine was not satisfactory.Conclusions:The patients in this group are mainly young and middle-aged males with the lesions on the head.Most cases belong to the chronic benign type.Histopathology reveals perifollicular mucin deposition with positive Alcian-blue staining,which suggests the diagnostic clue of follicular mucinosis.更多还原