【摘要】 目的 探讨不同剂量阿托伐他汀对直接经皮冠状动脉介入治疗术(PCI)后基质金属蛋白酶-9(MMP-9)和高敏C反应蛋白(hs-CRP)的影响。方法 96例接受直接PCI的急性心肌梗死(AMI)患者随机分为大剂量组和标准剂量组,两组各48例,于术前分别给予阿托伐他汀钙片40mg和20mg口服,术后两组分别继续每日睡前口服40mg和20mg持续1周,1周后均同为20mg睡前口服。于术前及术后24小时、72小时、1周和1个月测定血清MMP-9、hs-CRP水平。结果 两组hs-CRP、MMP-9水平PCI术后24小时均升高(P<0.01),术后72小时逐渐下降,术后1周低于术前(P<0.01);40 mg剂量组下降更显著。结论 AMI患者PCI术后使用大剂量阿托伐他汀不良反应无明显增加,可明显降低hs-CRP、MMP-9水平,减少炎症反应,保护血管内皮功能,预防支架内血栓形成。更多还原

【Abstract】 Objective To investigate the effects of different doses atorvastatin on the expression of matrix metalloproteinases(MMP-9) and high sensitive C-reactive protein(hs-CRP) in patients with acute myocardial infarction(AMI) after percutaneous transluminal coronary intervention(PCI).Methods96 patients with AMI underwent PCI were randomly divided into the high-dose group(re =48) and standard treatment group(n = 48),respectively gave 40 mg or 20 mg of atorvastatin calcium tablet in the preoperative oral,postoperative respectively continued after taking a week to 20 mg.The serum levels of MMP-9and hs-CRP were determined in the preoperative and postoperative 24 h,72 h,one week and one month.Double layer resistance ABC-ELISA were performed for measurement of MMP-9 and the concentration of hs-CRP was measured by immune turbidimetry.Results The levels of serm MMP-9 and hs-CRP in two groups were increased at 24 h(P<0.01).declined gradually at 72 h and decreased significantly at one week post-PCI(P <0.01).especially in treatment group.Conclusion High dose atorvastatin significantly reduced the levels of MMP-9 and hs-CRP.protected the vascular endothelial function,prevented stent thrombosis.更多还原