【摘要】 目的:研究双相抑郁患者前额叶皮质、前扣带回皮质代谢物的相对含量。方法:对30例未服药双相抑郁患者和30名健康志愿者的前额叶皮质、前扣带回皮质进行氢质子波谱(1H-MRS)扫描,双相抑郁患者经6周药物治疗后再次做1H-MRS扫描,检测N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、谷氨酸复合物(Glx)、肌酸(Cr)4种代谢物。结果:双相抑郁组左侧前额叶皮质、双侧前扣带回皮质NAA/Cr值均显著低于正常对照组(P<0.05),Cho/Cr值、Glx/Cr值均显著高于正常对照组(P<0.05),双相抑郁组右侧前额叶皮质NAA/Cr、Cho/Cr、Glx/Cr值两组比较差异无统计学意义(P>0.05)。经药物治疗后,左侧前额叶皮质、双侧前扣带回皮质NAA/Cr值较治疗前升高,Cho/Cr值、Glx/Cr值较治疗前降低,差异有统计学意义(P<0.05)。结论:前额叶和前扣带回皮质NAA、Cho、Glx含量的改变与双相抑郁的发生和药物的疗效有关。更多还原

【Abstract】 Objective: To measure the levels of metabolites in the prefrontal cortex and anterior cingulate cortex of patients with bipolar depression. Method:1H-MRS was performed on prefrontal cortex and anterior cingulated cortex in 30 unmedicated patients with bipolar depression and 30 healthy controls.The patients underwent 1H-MRS again after six weeks of drug treatment.The compounds measured were N-acetylaspartate(NAA),choline (Cho),glutamate/glutamine (Glx) and creatine (Cr). Results:Bipolar depressive patients had significantly lower NAA/Cr ratios in left prefrontal cortex and bilateral anterior cingulate cortex than healthy controls (P<0.05),and the patients had significantly higher Cho/Cr,Glx/Cr ratios in left prefrontal cortex and bilateral anterior cingulate cortex than healthy controls (P<0.05).No significant difference in NAA/Cr,Cho/Cr and Glx/Cr ratios were found in right prefrontal cortex between the two groups (P>0.05).After drug treatment,the ratios of NAA/Cr in left prefrontal cortex and bilateral anterior cingulate cortex were significantly increased compared with those before treatment (P<0.05),and the ratios of Cho/Cr,Glx/Cr in left prefrontal cortex and bilateral anterior cingulate cortex were significantly decreased compared with those before treatment (P<0.05). Conclusion:Alterations in the levels of NAA,Cho,Glx in prefrontal cortex and anterior cingulated cortex may be implicated in the pathogenesis of bipolar depression and are related to the efficacy of drug.更多还原