【摘要】 目的探讨抗着丝点蛋白B抗体(CENP-B)阳性血清抗核抗体(ANA)荧光模式及其临床应用价值。方法对96例抗CENP-B抗体阳性血清的ANA荧光模式、滴度、分布及临床诊断进行回顾性分析。结果 96例抗CENP-B抗体阳性血清中,单纯性抗CENP-B抗体阳性(+/-)为46例(47.9%),+/-组和+/+组的荧光模式比较,差异有统计学意义(P<0.01)。<1∶1 000和≥1∶1 000的核型滴度组抗CENP-B抗体阳性强度的差异有统计学意义(P<0.01);+/-组的自身免疫性疾病(AID)患者主要为系统性红斑狼疮、类风湿性关节炎、干燥综合征、系统性硬化症、原发性胆汁性肝硬化和雷诺综合征;非AID患者中,主要多见于脑梗死、贫血和Ⅱ型糖尿病患者。结论抗CENP-B抗体在脑梗死、贫血和Ⅱ型糖尿病患者中的较高表达值得关注。更多还原

【Abstract】 Objective To investigate the fluorescence patterns of anti-nuclear antibody(ANA) of positive serum of anti-centro- mere protein B(CENP-B) antibody and its clinical application values.Methods The fluorescence patterns,titers,distribution of ANA of 96 samples of anti-CENP-B antibody-positive serum and clinical diagnosis were retrospectively analyzed.Results Among 96 samples of anti-CENP-B antibody-positive serum,46(47.9%) samples were found simple anti-CENP-B antibody positive(+/-),Compared with fluorescence patterns in +/- group and +/+ group,difference had statistical significance(P<0.01). Difference of anti-CENP-B antibody intensity between<1∶1000 and ≥1∶1000 karyotype titer groups showed statistical signifi- cance(P<0.01).Systematic lupus erythematosus,rheumatoid arthritis,Sjogren′s syndrome,systemic sclerosis,primary biliary cir- rhosis,and Raynaud′s syndrome were the main disease which were found in patients with autoimmune diseases(AID)in +/- group,while cerebral infarction,anemia and typeⅡ diabetes were mainly prevalent in non-AID patients.Conclusion It should be pay attention for the high expression of anti-CENP-B antibody in patients with cerebral infarction,anemia and typeⅡ diabetes.更多还原