【摘要】 目的通过对慢性心力衰竭(chronic heart failure,CHF)患者血清脑钠肽(brain natriuretic peptide,BNP)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)及白细胞介素-6(interleukin-6,IL-6)水平的检测,探讨其与CHF的关系。方法选择53例CHF患者作为CHF组,20例同期健康体检者作为对照组,采用电化学发光免疫分析法测定其血清BNP的水平,酶联免疫吸附试验测定其血清MMP-9、IL-6的浓度,通过超声心动图检查,分别测定CHF组与对照组的左心室射血分数(left ventricular ejection fraction,LVEF)、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end-systolic diameter,LVESD),并采用SPSS 19.0软件进行统计学分析。结果 CHF组患者血清BNP、MMP-9及IL-6水平显著高于对照组,差异均有统计学意义(P均<0.05);CHF组患者LVEDD、LVESD较对照组明显增加,LVEF较对照组明显下降,差异均有统计学意义(P均<0.05);CHF组患者血清BNP、MMP-9、IL-6水平与LVEDD、LVESD均呈正相关关系,而与LVEF呈负相关关系(P均<0.05)。结论血清BNP、MMP-9、IL-6水平可较好地反映出CHF患者的心脏功能状态,在CHF的发生、发展过程中起重要作用,是诊断CHF的良好指标。更多还原

【Abstract】 Objective To investigate the relationship of chronic heart failure(CHF) with serum levels of brain natriuretic peptide(BNP),matrix-9(MMP-9) and Interleukin-6(IL-6).Methods 53 cases CHF patients(CHF group) and 20 cases healthy people(control group) were selected.Serum BNP was detected by electrochemiluminescence immunoassay.Serum MMP-9 and IL-6 were detected by enzyme-linked immunosorbent assay.Left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),and left ventricular end-systolic diameter(LVESD) in CHF group and control group were analyzed by echocardiogram.All data were analyzed by SPSS 19.0 statistical software.Results Serum levels of BNP,MMP-9 and IL-6 in CHF group were higher than in control group,and the differences all had statistical significance(Pall< 0.05).LVEDD and LVESD in CHF group were higher than in control group,and LVEF in CHF group was lower than in control group,and the differences all had statistical significance(Pall< 0.05).In CHF group,levels of BNP,MMP-9 and IL-6 had positive correlation with LVEDD and LVESD,and had negative relation with LVEF(Pall< 0.05).Conclusion Serum levels of BNP,MMP-9,IL-6 can reflect the CHF patients with cardiac function state better,and play an important role in the occurrence and process in CHF.They are good index to CHF diagnosis.更多还原