【摘要】 铂金属配合物因其卓著的疗效已迅速发展为临床治疗癌症的重要药物,本文设计并合成了三联吡啶铂(II)配合物1,通过核磁及质谱等实验表征了目标分子的结构,通过温度依赖性核磁、溶剂依赖性紫外可见光谱等实验证明了酰胺分子间的氢键、π-π堆积以及Pt-Pt金属-金属相互作用是配合物1在自组装过程中的主要驱动力,通过透射电镜观测到组装体的形貌为单分子纳米纤维结构,该研究有利于阐明铂类化合物的自组装行为与其抗癌活性的联系性。更多还原

【Abstract】 Platinum(II)ligand complexes have become one of the important drugs for anti-cancer therapy. In this paper,terpyridineplatinum(II)complex 1 was successfully designed and synthesized,which was proved by NMR and mass spectrometry. By means of temperature dependent 1H NMR and UV-vis absorption measurements,it is evident that hydrogen bonds between intermolecular amide groups,π-π stacking and Pt-Pt metal-metal interactions were the main driving forces during self-assembly. Moreover,nanofibers were clearly observed by TEM measurement. The current study is helpful to identify the relationships between the structure and anti-cancer properties of platinum drugs.更多还原