【摘要】 目的探讨过敏性疾病病人外周血中EB病毒(EBV)各种抗体的表达与过敏性疾病的相关性。方法收集71例过敏性疾病(包括过敏性哮喘、过敏性鼻炎、湿疹和荨麻疹)病人和40例健康查体者(健康对照组)外周血标本,应用半定量酶联免疫吸附试验(ELISA)方法,检测EBV早期抗原(EA)-IgA、EA-IgM、EBV衣壳抗原(VCA)-IgG、VCA-IgA和VCA-IgM抗体水平。结果过敏性疾病病人外周血EA-IgM、EA-IgA和VCA-IgM水平显著高于健康对照组(t=3.18～5.74,P<0.01),VCA-IgG和VCA-IgA水平两组比较差异无显著性(P>0.05)。结论 EBV抗体EA-IgM、EA-IgA和VCA-IgM可能参与过敏性疾病发病。更多还原

【Abstract】 Objective To investigate the Epstein-Barr virus(EBV)antibodies in patients with anaphylactic diseases. Methods Blood samples of 71patients with anaphylactic diseases including allergic asthma,allergic rhinitis,eczema and hives, and 40healthy controls were collected.Early antigens(EA)EA-IgA and EA-IgM,EBV VCA-IgG and VCA-IgA,as well as VCAIgM antibody were detected by ELISA. Results The blood levels of EA-IgM,EA-IgA and VCA-IgM in the patients were higher than that in the healthy controls(t=3.18-5.74,P<0.01),but no significant differences were noted between the two groups with regard to VCA-IgG and VCA-IgA(P>0.05). Conclusion The EBV antibodies EA-IgM,EA-IgA and VCA-IgM are likely to be involved in the development of anaphylactic disease.更多还原