【摘要】 目的:探讨普通干扰素联合利巴韦林优化方案治疗慢性丙型肝炎的疗效。方法:将120例基因1b型丙型肝炎患者分为普通干扰素优化方案组、普通干扰素标准方案组、聚乙二醇干扰素α-2α(PEG-IFNα-2α)方案组,比较各组在治疗过程中快速病毒学应答(RVR)、早期病毒学应答(EVR)、治疗结束时病毒学应答(ETVR)、持续病毒学应答(SVR)及丙氨酸氨基转移酶(ALT)指标。结果:普通干扰素优化方案组、聚乙二醇干扰素α-2α方案组获得的EVR、ETVR及SVR均高于普通干扰素标准方案组。结论:根据慢性丙型肝炎治疗过程中的应答情况来调整干扰素用量的方案,可以提高干扰素的抗病毒疗效。更多还原

【Abstract】 Objective: To discuss the efficacy of optimization in antiviral treatment for chronic hepatitis C by interferon combined with ribavirin. Method: 120 cases infected with genotype 1b HCV were divided into three groups,including the optimization interferon group, the standard interferon group, and the PegIFN α-2α(Pegasys) group. Rapid virological response (RVR), early virological response (EVR), end treated virological response, sustained viral response (SVR) and alanine transaminas (ALT) were observed respectively. Result: The incidence of EVR, ETVR, SVR in the optimization interferon group and the PegIFN α-2α(Pegasys) group were higher than that of the interferon standard group (P<0.05). Conclusion: Adjusting the dose of interferon in treating chronic hepatitis C according to on-treatment virologic response can improve efficacy.更多还原