【摘要】 【目的】探讨入肝门静脉动脉化加门腔分流术对肝硬化大鼠肝功能的影响。【方法】125只肝硬化大鼠随机分为A组(n=50),入肝门静脉完全动脉化+门腔分流;B组(n=50),仅行门腔完全分流;C组(n=25),门静脉阻断30 min+右肾切除。分别检测各组大鼠术前、术后1、2、4及8周血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TB)、白蛋白(ALB)及吲哚氰氯15 min潴留率(ICGR15)。【结果】术前各组大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TB)、白蛋白(ALB)及ICGR15无明显差异(P>0.05);术后随着时间推移,A组大鼠的ALT、TB、AST及ICGR15较B、C两组均有明显降低,差异有明显统计学意义(AST:P<0.05,其他指标P<0.01),并于术后2周后,可达到稳态;而A组ALB术后较B、C两组明显升高,差异也有显著统计学意义(P<0.01),并于术后4周可达到稳态。【结论】入肝门静脉动脉化重建入肝血流能明显促进肝硬化大鼠肝功能恢复,有助预防门腔分流术后肝功能衰竭。更多还原

【Abstract】 【Objective】 To evaluate the effects on liver function following portal vein arterializations(PVA) associated with portocaval shunt(PCS) in cirrhotic rats.【Method】A total of 125 cirrhotic rats were randomly divided into three groups: Group A(n=50),PVA+PCS;Group B(n=50),PCS only;Group C(n=25),portal vein block for 30 min + right nephrectomy.The serum level of alanine aminotransferase(ALT),glutamic-oxalacetic transaminease(AST),total bilirubin(TB),albumin(ALB) and ICGR15 was measured at the moment of pre-operation,postoperative 1 week,2 weeks,4 weeks,and 8 weeks in each group,respectively.【Results】 No preoperative significant difference was observed in the serum level of ALT,AST,TB,ALB and ICGR 15 in three groups(P > 0.05).The serum level of ALT,AST,TB,and ICGR 15 in Group A maintain a significant lower level than the other two groups(Group B and Group C) after surgery(AST: P < 0.05,others:P < 0.01).Otherwise,the serum level of ALB in Group A was significantly higher than the other two groups(P < 0.01).The serum level of ALT,TB and ICGR15 reached a steady state in postoperative 2 weeks,and the serum level of ALB maintained stably untill postoperative 4 weeks.【Conclusion】 The PVA procedure bring beneficial effects on liver function in cirrhotic rats.When associated with PCS,it should help to prevent liver failure.更多还原