【摘要】 目的观察苗药香囊对正常小鼠肺泡灌洗液及血清IL-2、IL-18水平的影响。方法雄性昆明小鼠50只,随机分为5组,即空白对照组、玉屏风颗粒组(阳性对照组)、香囊持续吸入组、香囊间断吸入组和香囊持续吸入+玉屏风颗粒组(香+玉组)。连续用药1个月后采用ELISA试剂盒检测灌洗液及血清中IL-2、IL-18水平的变化。结果香囊持续吸入组肺泡灌洗液IL-2和IL-18的含量分别为(90.99±10.27)pg/ml和(175.29±71.60)pg/ml,显著高于空白对照组的(54.08±23.49)pg/ml和(85.66±28.19)pg/ml,差异具有统计学意义(P<0.05)。结论苗药香囊能够增加正常小鼠呼吸道中IL-2和IL-18的含量,进而增强正常小鼠呼吸道黏膜的局部免疫功能。更多还原

【Abstract】 Objective To observe the influences of miaoyaoxiangnang on secretory interleukin 2 ( IL-2) and interleukin 18 ( IL-18) in fluid of bronchoalveolar lavage and serum of healthy mice. Methods Total of 50 kunming mice were randomly divided into normal control ( NC) group,yupingfengkeli ( YPFKL) group,continuous inhalation of xiangnang ( CIOXN) group,intermittent inhalation of xiangnang ( IIOXN) group,CIOXN + YPFKL group ( n = 9 in each group) . All mice in 5 groups were treated for one month. The levels of IL-2 and IL-18 in fluid of bronchoalveolar lavage and serum were detected by an ELISA kit, respectively. Results Compared with NC group,the levels of IL-2 and IL-18 in fluid of bronchoalveolar lavage in CIOXN group were significantly higher ( P < 0. 05 ) . Conclusions Miaoyaoxiangnang could enhance the levels of IL-2 and IL-18 in the respiratory tract of healthy mice,which may mainly increase the respratory mucosal immune function of the mouse.更多还原