【摘要】 目的:探讨99Tcm-硫化铼胶体在乳腺癌前哨淋巴结(SLN)活检中的应用价值。方法:30例T1～T2期乳腺恶性肿瘤患者入选,术前15～24 h乳晕下注射99Tcm-硫化铼,使用SPECT/CT进行SLN淋巴显像,定位;术中用γ探测仪寻找SLN,行SLN活检后,常规行乳癌手术;术后对SLN活检和腋窝淋巴结(ALN)清扫的病理结果进行比较分析。结果:30例共有29例检到SLN,共检出SLN 31枚,检出率,准确率分别为97.67%,100%;SLN状态与腋淋巴结转移的符合率为100%,无假阳性及假阴性情况出现。结论:99Tcm-硫化铼用于乳腺癌SLN活检是一种较理想的核素示踪剂。更多还原

【Abstract】 Objective: To investigate the clinical application value of 99Tcm-colloidal rhenium sulfide in sentinel lymph nodes(SLNs) biopsy in patients with breast cancer. Methods: Thirty patients with T1–T2 breast cancer were enrolled.Patients were injected with 99Tcm-colloidal rhenium sulfide under the areola 15–24 h before operation,and lymphoscintigraphy and mapping of the SLNs was subsequently performed with SPECT/CT.Gamma probe-guided SLNs detection and biopsy was employed during surgery before the breast cancer resection.The results of SLN biopsy and histological examination were compared and analyzed after surgery. Results: SLNs were detected in 29 of the 30 patients and a total of 31 SLNs were identified.The detection rate and accuracy rate was 97.67% and 100%,respectively.The coincidence rate of the SLNs status and axillary lymph node metastasis was 100%,and no false positive or negative detections occurred. Conclusion: 99Tcm-colloidal rhenium sulfide is an ideal tracer for SLNs biopsy in patients with breast cancer.更多还原