【摘要】 目的:探讨氧疗对老年非小细胞肺癌放疗增敏作用的治疗价值。方法:56例经病理证实的老年非小细胞肺癌患者,分为高-低氧疗+放疗组(研究组)28例,单纯放疗组(对照组)28例,两组均给予三维适形放疗(3DCRT),总剂量50～66 Gy/25～33次,其中,研究组放疗前给予5升/分的高流量吸氧2小时,吸氧结束后即给予放疗,放疗结束后给予持续3升/分低流量吸氧至次日放疗前2小时,对照组不予吸氧。结果:研究组近期总有效率为96.4%,对照组近期总有效率为71.4%,两组比较差异有统计学意义(P<0.05);治疗中急性放射性肺炎的发生率低于单纯放疗组(P<0.05)。结论:与单纯放疗相比,高-低氧放疗能提高老年非小细胞肺癌近期疗效,同时能降低急性放射性肺炎不良反应。更多还原

【Abstract】 Objective:To study the efficacy of radiosensitization in elderly non-small cell lung cancer on oxygen therapy.Methods:56 cases of elderly non-small cell lung cancer patients were confirmed by pathology were assigned into two groups equally at random.28 cases were on oxygen and radiotherapy(experimental group),28 cases were on radiotherapy alone(control group).Two groups were treated by three dimensional-conformal radiotherapy(3DCRT),DT50~66Gy/25~33fx.Experimental group was on high-flow oxygen(5liters/min)for 2 hours before radiotherapy,then was radiated after the end of oxygen therapy.After radiotherapy,experimental group was treated by low-flow oxygen(3liters/min)until 2 hours before radiotherapy.The control group was not treated by oxygen during radiotherapy.Results: Experimental group was the recent effective rate of 96.4%,the control group was 71.4%;the difference between two groups was statistically-significant(P<0.05).The incidence of acute radiation pneumonitis in radiotherapy alone group was lower(P<0.05).Conclusions: Oxygen therapy may improve short-term efficacy of elderly non-small cell lung cancer and lower the side effect of acute radiation pneumonitis.更多还原