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18F-FLT PET/CT显像在肿瘤分期和治疗策略中的应用

Clinical Application of 18F-FLT PET/CT in Staging and Treatment of Carcinoma as Compared with CT

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【作者】 王建平； 翟小明； 邓胜明； 章斌； 吴翼伟； 范我； 刘建军；

【Author】 Wang Jianping1,Zhai Xiaoming1,Deng Shengming2,Zhang Bin2,Wu Yiwei2,Fan Wo2,Liu Jianjun3 1.Department of Radiation Oncology,The First Hospital Affiliated to Soochow University,Suzhou 215006,China,2.Department of Nuclear Medicine;3.Department of Nuclear Medicine,Renji Hospital Affiliated to Shanghai Jiaotong University

【机构】 苏州大学附属第一医院放疗科； 苏州大学附属第一医院核医学科； 上海交通大学附属仁济医院核医学科；

【摘要】 目的探讨18F-FLT PET/CT融合影像对肿瘤TNM分期及治疗策略的影响。方法对23例恶性肿瘤患者分别用全身CT图像和18F-FLT PET/CT融合图像进行TNM分期。观察两种分期方法的差异;并结合临床资料调整治疗策略。结果 (1)18F-FLT PET/CT显像后有7例T分期和(或)N分期和(或)M分期发生改变,其中4例T分期、3例N分期和1例M分期发生改变;4例总分期发生改变。两种分期之间差异无统计学意义(P>0.05);(2)有3例改变了治疗策略。结论 18 F-FLT PET/CT显像可使肿瘤分期更准确;并通过优化治疗方案,使肿瘤患者获得更好的治疗效益。

【Abstract】 Objective To explore the clinical application value of positron emission tomography-computed tomography using 18F-FLT.Methods Staging of TNM for a total of 23 patients with carcinoma was assessed with both 18F-FLT PET/CT and CT alone.The treatment strategy can be adjusted according to the result of 18F-FLT PET/CT and clinical data.Results(1)The TNM defined by CT was altered by 18F-FLT PET/CT in 4 of 23 cases.There was no significant difference between PET/CT and CT for the TNM staging(P>0.05).T staging was changed in four cases,N staging was changed in three cases,and M staging was changed in only one case.(2)The treatment strategies for three cases have been changed.Conclusion 18F-FLT PET /CT fusion imaging allowed more accurate staging A better treatment efficacy can be obtained by optimizing the treatment strategy.

【关键词】 18F-FLTPET/CT； CT； 肿瘤； 分期； 治疗策略；
【Key words】 18F-FLT PET/CT； CT； Carcinoma； Staging； Treatment strategy；
【基金】 苏州市科技计划资助项目(SYS201117)
  • 【文献出处】 肿瘤防治研究 ,Cancer Research on Prevention and Treatment , 编辑部邮箱 ,2012年12期
  • 【分类号】R730.5
  • 【被引频次】5
  • 【下载频次】150
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