【摘要】 在雷帕霉素产生菌吸水链霉菌FC904突变株FC904-107的发酵液中发现一个雷帕霉素同系物FIM-4025,用反相硅胶柱层析等提取纯化并获得晶体。经理化性质、UV、IR、LC-MS、NMR等波谱分析,单晶X-Ray衍射确定构型,结果表明雷帕霉素同系物FIM-4025与雷帕霉素化学半合成的衍生物7-O-乙基雷帕霉素同质。更多还原

【Abstract】 A rapamycin analogue FIM-4025 was isolated from a mutant of rapamycin producing strain Streptomyces hygroscopicus FC904-107 during the fermentation.The chemical structure of FIM-4025 was identical with a chemical semisynthesis rapamycin derivative,7-O-ethyl-apamycin,which was analysed by UV,IR,MS,NMR and X-ray single crystal diffraction,respectively.更多还原