【摘要】 目的:探讨乌司他丁对老年患者全麻开胸手术炎症反应及S100β蛋白的影响。方法:择期普通开胸手术老年患者100例,随机分为对照组和乌司他丁组,每组50例。乌司他丁组在麻醉后静脉泵注乌司他丁2×104U.kg-1,对照组则以等量的生理盐水泵注。术前、术后4 h及24 h取静脉血2 mL,用ELISA法测定血浆肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)以及S100β蛋白的质量浓度。结果:对照组和乌司他丁组在术后血浆TNF-α、IL-6水平均较手术前明显升高(P<0.05),但乌司他丁组升高的水平显著低于对照组(P<0.05)。术前和术后24 h,对照组和乌司他丁组S100β蛋白质量浓度差异无统计学意义;术后4 h,乌司他丁组S100β蛋白质量浓度显著低于对照组。结论:乌司他丁可明显抑制老年开胸患者术后炎症因子的过度释放,降低血浆S100β蛋白上升的水平,减轻中枢神经系统的损伤。更多还原

【Abstract】 Objective:To investigate the effects of ulinastatin on systemic inflammatory response and on S100β protein after thoracotomy in elderly patients with general anesthesia.Methods:One hundred senior patients,undergoing elective general open chest operation were randomly divided into 2 groups:control group(n=50) and ulinastatin group(n=50).In ulinastatin group,ulinastatin(2×104 U/kg) was infused intravenously by pump after the induction of anesthesia;while in control group,equal volume of normal saline was given instead of ulinastatin.Two milliliters of blood samples were taken from vein before operation beginning,4 h and 24 h after operation termination for determination of TNF-α,IL-6 and S100β protein by means of ELISA.Results:The concentration of TNF-α and IL-6 elevated dramatically after operation in both groups(P<0.05),but TNF-α and IL-6 in ulinastatin group were lower than that at the corresponding time point in control group(P<0.05).The levels of S100β protein were not significantly different before operation and 24 h after operation between two groups,while 4 h after operation the levels of S100β protein in ulinastatin group were lower compared with control group.Conclusion:Ulinastatin could decrease systemic inflammatory response and blood levels of S100β protein after thoracotomy in senior patients,thus decreasing injury to the nervous system.更多还原