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RNA干扰及在刚地弓形虫研究中的应用
RNA interference and its use in Toxoplasma gondii research
【摘要】 刚地弓形虫病严重危害人类健康,是非常严重的公共卫生问题,弓形虫病的防治刻不容缓,寻找安全有效的防治措施是控制弓形虫病的重点和难点。RNA干扰技术可以抑制特定基因的表达,具有普遍性、高效性、特异性等优点,是研究弓形虫基因组功能、筛选新的疫苗和药物靶点的强有力的工具。本文综述了近几年来RNA干扰的研究进展及其在刚地弓形虫研究中的应用。
【Abstract】 Toxoplasmosis imperils humans,health and has been an important public health problem.The prevention and control of T.gondii is imperative,and safe and effective measures to control the disease must be determined.RNA interference can block particular gene expression.Because of its ubiquity,efficiency,and specificity,RNA interference technology has become a powerful tool for the study of gene function and screening new vaccines and drug targets.This article reviews recent advances in the study of RNA interference and its application to T.gondii.
【Key words】 RNA interference; small interference RNA; toxoplasma gondii; application; review;
- 【文献出处】 中国病原生物学杂志 ,Journal of Pathogen Biology , 编辑部邮箱 ,2012年09期
- 【分类号】R382.5
- 【被引频次】1
- 【下载频次】189