【摘要】 目的了解东营市人民医院临床分离病原菌的种类及对常用药物的耐药性,为临床抗菌药物经验选用提供参考。方法对医院2011年分离菌株的种类及其药敏结果采用WHONET5.4软件进行数据分析。结果 2011年共收集非重复临床分离菌株1272株,其中革兰阴性菌868株占68.24%,革兰阳性菌284株占22.33%;真菌120株占9.43%;除万古霉素、替考拉宁、夫西地酸、喹奴普汀/达福普汀外,耐甲氧西林金黄色葡萄球菌(MRSA)对其他测试药物的耐药率均>60.0%;肺炎克雷伯菌、大肠埃希菌产ESBLs菌检出率分别为50.8%、59.1%;除碳青霉烯类外产ESBLs菌对其他测试药物的耐药率均显著高于非产ESBLs株,未发现对碳青霉烯类耐药菌株;铜绿假单胞菌检出率与耐药性无明显变化,对哌拉西林/他唑巴坦、阿米卡星、头孢西丁敏感性均>70.0%;鲍氏不动杆菌检出率及耐药性明显增长,除碳青霉烯类外,其余测试药物敏感率均<35.0%;首次发现4株同时耐碳青霉烯类抗菌药物的鲍氏不动杆菌。结论 2011年临床分离菌对常用抗菌药物的耐药性呈增长趋势,首次发现多药耐药的鲍氏不动杆菌,应加强抗菌药物的临床应用管理和医院感染的控制。更多还原

【Abstract】 OBJECTIVE To investigate the species and the drug resistance to common antibacterials of the pathogenic bacteria isolated from inpatients of Dongying People′s Hospital,so as to provide reference for the clinical selection of antibiotics.METHODS The species of the kinds of microorganisms isolated during year 2011 and their antibacterial-resistance were analyzed by software WHONET5.4.RESULTS A total of 1272 clinical isolates of non-repeated bacteria were isolated,including 868(68.23%)strains of gram-negative bacteria,284(22.32%)strains of gram-positive bacteria,and 120(9.43%)strains of fungi.The drug resistance rates of methicillin-resistant Staphylococcus aureus(MRSA)to all the antibiotics except vancomycin,teicoplanin,fusidic acid,and quinupristin/dalfopristin were higher than 60.0%.The positive rates of ESBLs-producing Klebsiella and Escherichia coli were 50.8% and 59.1%,Except carbopenems,the drug resistance rate of the ESBLs-producing strains to all the antibiotics except carbapenems was significantly higher than that of the non-ESBLs-producing strains,and no strains of carbopenems-resistant strains were found.The detection rate and drug resistance of Pseudomonas aeruginosa varied little,the drug susceptibility rates to piperacillin/tazobactam,amikacin and cefoxitin were higher than 70.0%.The detection rate and drug resistance of Acinetobacter baumannii increased significantly,the drug susceptibility rate was less than 35.0% to all the tested antibiotics except carbopenems,four strains of A.baumannii strains simultaneously resistant to carbapenems were first reported.CONCLUSION The drug resistance of clinical isolates of bacteria to common antibacterials shows an upward tendency during the year 2011,the multidrug-resistant A.baumannii isolates are first detected,thus it is necessary to strengthen the clinical application management of antibiotics so as to control the nosocomial infections.更多还原