【摘要】 目的了解耐亚胺培南鲍氏不动杆菌(IRAB)医院感染的临床分布及耐药性,为临床合理使用抗菌药物提供依据。方法采用VITEK-32全自动细菌鉴定药敏系统及纸片扩散法(K-B法)测定鲍氏不动杆菌对15种抗菌药物的敏感性。结果 106株IRAB中,分离率居前3位的临床科室依次为ICU、呼吸内科、神经内科,分别占51.9%、12.3%、8.5%;临床标本中以呼吸道标本分离率最高,占68.9%;106株IRAB除对头孢哌酮/舒巴坦的耐药率<10.0%,对其他抗菌药物的耐药率均>57.6%。结论 IRAB医院感染和多药耐药性严重,出现了泛耐药菌株,医院应重视抗菌药物使用管理,尤其要关注泛耐药菌株的产生与流行。更多还原

【Abstract】 OBJECTIVE To explore the clinical distribution of imipenem-resistant Acinetobacter baumannii(IRAB) infections and their drug resistance in order to provide reference for the rational use of antibiotics.METHODS Drug susceptibility of A.baumannii to 15 antibacterials was determined by VITEK-32 full-automatic bacterial identification susceptibility system and disk diffusion method(K-B method).RESULTS Of 106 strains of IRAB,the top 3 isolation rates were found in ICU(51.9%),department of respiratory medicine(12.3%),and department of neurology(8.5%).The rate of the isolation from respiratory tract specimens was the highest(68.9%).Most drug resistance rate of 106 strains of IRAB was higher than 57.6% except to cefoperazone/sulbactam,which was lower than 10.0%.CONCLUSION Nosocomial infections caused by IRAB and multidrug-resistance are serious.Pan-drug resistant strains have emerged,and the hospital should pay attention to the application of antibiotics,focusing on the emergence and prevalence of pan-drug resistant strains.更多还原