【摘要】 目的探讨重症监护病房(ICU)中大肠埃希菌的感染现状及耐药性,为临床合理使用抗菌药物提供依据。方法对ICU 2008年1月-2010年7月医院感染的233株大肠埃希菌(ECO)及其耐药性进行回顾性分析。结果大肠埃希菌产超广谱β-内酰胺酶(ESBLs)率为88.8%;ECO对常用抗菌药物产生了耐药性,其中对氨苄西林耐药率最高,达98.2%～100.0%,对亚胺培南和美罗培南敏感率最高,为99.5%。结论 ICU中ECO的感染及耐药问题日益严重,需要加强ICU耐药菌监控,预防医院感染暴发流行。更多还原

【Abstract】 OBJECTIVE To investigate the infection status and drug resistance of Escherichia coli(ECO) in Intensive care unit(ICU) of our hospital,and provide the etiological evidence for reasonable use of antibiotics.METHODS The clinical data of 233 nosocomial infection cases with ECO from Jan 2008 to Jul 2010 in ICU of our hospital and their drug resistance were investigated retrospectively.RESULTS The detection rate of extended spectrum β-lactamases(ESBLs) producing ECO was 88.8%.Drug susceptibility test results showed ECO had been resistant to commonly used antibiotics to varying extents.The highest rate of resistance(98.2%-100.0%) was to ampicillin.The highest rate of susceptibility(99.5%) was to imipenem and meropenem.CONCLUSION ECO infections in ICU and the drug resistance become increasingly serious.To strengthen the monitoring on the resistant strains in ICU is required to prevent outbreak and epidemic of nosocomial infections.更多还原