【摘要】 目的:进行不同产地的北细辛和华细辛镇痛抗炎药效学评价。方法:以醋酸扭体试验、热板试验对细辛进行镇痛作用评价;以二甲苯致鼠耳肿胀试验对细辛进行抗炎作用评价。结果:12个不同产地的北细辛和华细辛样品均有镇痛和抗炎作用,疼痛抑制率7个北细辛样品在27%～61%,5个华细辛样品在40%～59%。6个产地北细辛的炎症抑制率(50%～70%)强于5个产地的华细辛炎症抑制率(34%～48%)。不同产地同一品种的细辛镇痛抗炎作用差异显著。北细辛:醋酸扭体实验结果显示4个吉林产细辛镇痛作用(38%～57%)均强于黑龙江产细辛(34%);热板实验结果显示黑龙江产细辛镇痛作用(43%)强于2个辽宁产细辛(29%～36%)。华细辛:醋酸扭体实验显示3个陕西产细辛镇痛作用(47%～49%)均强于湖北产细辛(40%);热板实验显示3个陕西产细辛镇痛作用(45%～59%)强于重庆产细辛(40%)。鼠耳肿胀实验结果显示北细辛4个吉林产细辛抗炎作用(51%～63%)均优于黑龙江产细辛(50%)。道地性分析表明,北细辛及华细辛道地药材的镇痛作用有强于各自非道地药材的趋势;北细辛道地药材的抗炎作用较非道地药材强,但华细辛道地药材和非道地药材在抗炎作用方面无明显差异。结论:不同产地的细辛均有镇痛抗炎作用,但作用强度明显不同,显示细辛具有一定程度的道地性。更多还原

【Abstract】 Objective: To assess the anti-nociception and anti-inflammation pharmacodynamics of Asarum heterotropoides var.mandshuricum and A.sieboldii.Method: Both the writhing test and hot plate test were conducted to assess the anti-nociceptive effect of Asarum and Xylene-induced mouse ear edema was conducted to assess the anti-inflammatory effect of Asarum.Result: Twelve samples of A.heterotropoides var.mandshuricum and A.sieboldii from different producing areas showed anti-nociceptive and anti-inflammatory effects.Specifically,27% to 61% of the seven samples of A.heterotropoides var.mandshuricum showed anti-nociceptive effect and while 34% to 48% of A.sieboldi showed anti-nociceptive effect.The inflammatory inhibition rate of A.heterotropoides var.mandshuricum produced in six producing areas(38%-57%) is higher than that of A.heterotropoides var.mandshuricum produced in five producing areas(34%-48%).The same kind of Asarum produced in different areas showed significant differences.A.heterotropoides var.mandshuricum produced in Jilin province(38%-57%) showed better anti-nociceptive effect than sample produced in Heilongjiang province(34%) in writhing test.A.heterotropoides var.mandshuricum produced in Heilongjiang(43%) province showed a better anti-nociceptive effect than samples produced in Liaoning province(29%-36%) in hot plate test.A.sieboldii produced in Shaanxi province(47%-49%) showed a better anti-nociceptive effect than samples produced in Hubei province(40%) in writhing test.A.sieboldii produced in Shaanxi province(45%-59%) showed better anti-nociceptive effect than samples produced in Chongqing(40%) in hot plate test.A.heterotropoides var.mandshuricum produced in Jilin province(51%-63%) showed better anti-inflammatory effect than samples produced in Heilongjiang province(50%).In totality,the results from analysis of geoherbalism showed that famous-region A.heterotropoides var.mandshuricum and A.sieboldii had a better anti-nociception effect than Asarum produced in other producing areas.famous-region A.heterotropoides var.mandshuricum had a better effect than those produced in other producing areas in anti-inflammation.But famous-region A.sieboldii showed no obvious difference from those produced in other producing areas in anti-inflammation.Conclusion: All samples of Asarum showed anti-nociceptive and anti-inflammatory effects,but with significant differences among Asarum produced in different areas,indicating the eoherbalism to some extent. [更多还原