【摘要】 目的采用诊断试验Meta分析综合评价抗环瓜氨酸肽抗体(CCP)和血清学指标类风湿因子(RF)筛查类风湿性关节炎(RA)的效果。方法通过检索万方、维普、CNKI等数据库,获得有关抗CCP和RF诊断筛查RA的文献,提取相关数据;采用DPS6.5进行诊断试验Meta分析。结果抗CCP的综合准确度为0.831,诊断优势比为24.154;RF的综合准确度为0.765,诊断优势比为10.540;抗CCP的诊断准确度高于RF(P<0.01)。结论抗CCP诊断RA能获得较好的特异度,而RF诊断RA能获得较好的灵敏度;若能联合抗CCP和RF,对RA具有较高的诊断价值。更多还原

【Abstract】 Objective To comprehensively assess the efficacy of anti-CCP and RF in rheumatoid arthritis(RA) screening using Meta-analysis.Method The papers related to anti-CCP and RF in RA screening were searched in Wanfang,Weipu,CNKI databases and the relative date was acquired.Meta-analysis was conducted using DPS 6.5 software.Results The TPR of anti-CCP was 0.831 and diagnostic OR was 24.154.The TPR of RF was 0.765 and diagnostic OR was 10.540.The accuracy of anti-CCP was much higher than RF(P<0.01).Conclusion The specificity of anti-CCP is higher than that of RF.However,the sensitivity of RF is higher than that of anti-CCP.The combination of RF and anti-CCP has meaningful value for the diagnosis of RA.更多还原