【摘要】 目的:筛选九头狮子草解热作用有效部位。方法:雄性SD大鼠,经筛选后随机分为正常对照组、模型对照组、石油醚组、醋酸乙酯组、正丁醇组、水组和水提组,采用干酵母皮下注射方法制备发热模型,于模型制备后5 h,分别ip石油醚部位(0.4 g.kg-1)、醋酸乙酯部位(0.4 g.kg-1)、正丁醇部位(0.4 g.kg-1)、水部位(1.4 g.kg-1)、水提液(8 g.kg-1)后分别于各个时间点监测直肠温度,比较各部位对大鼠发热曲线、直肠温度及最大发热高度(△T℃)、体温反应指数(TRI9)的影响。结果:九头狮子草水提液,石油醚部位及水部位均能降低发热模型大鼠体温,其差异具有显著性(P<0.05)。三者对TRI9的影响分别为(10.2±0.8),(8.2±0.6),(10.1±0.5),与模型组比较,差异具有显著性(P<0.05)。结论:九头狮子草水提液,石油醚部位及水部位均具有解热作用,石油醚部位及水部位解热作用强于九头狮子草水提液,为九头狮子草解热有效部位。更多还原

【Abstract】 OBJECTIVE To study the antipyretic effects of active extracts of Peristrophe japonica.METHODS The rat febrile models induced by injecting fresh yeast subcutaneously were treated with water extract of Peristrophe japonica and four fractions(including ligarine fraction,Et Ac fraction,n-butanol fraction and water fraction),then the rectal temperature was monitored to show the differences of effect from those groups.RESULTS Three drug administration groups(including water extract of Peristrophe japonica,ligarine fraction and water fraction) showed marked antipyretic effect on the yeast-induced fever(P<0.05) and the effects were stronger in the ligarine fraction and water fraction groups than in the water extract of Peristrophe japonica group.CONCLUSION The water extract of Peristrophe japonica,ligarine fraction and water fraction all have obvious antipyretic effect,but the effect of ligarine fraction and water fraction are stronger than that of water extract of Peristrophe japonica,which might be the active extracts of Peristrophe japonica of antipyretic effect.更多还原