【摘要】 目的测定缺氧缺血性脑病(HIE)新生儿血浆8-异前列腺素F2α(8-iso-PGF2α)水平及其盐酸氨溴索应用前后变化,探讨HIE的脂质过氧化损伤机制及盐酸氨溴索的抗氧化效果。方法 HIE(中度)足月儿51例,随机分为常规治疗组(26例)和氨溴索治疗组(25例)。另选正常足月儿25例作为正常对照组。常规组采用一般常规治疗方案;氨溴索组在常规治疗基础上加用氨溴索30mg/(kg.d)。治疗于生后第1天开始,3d为1个疗程。于治疗前后(生后第1、3、7天)收集外周血,酶联免疫法检测血浆8-iso-PGF2α浓度。结果 (1)治疗前,常规治疗组和氨溴索治疗组患儿血浆8-iso-PGF2α水平均明显高于正常新生儿水平,差异有高度统计学意义(P<0.01)。(2)治疗后第7天,常规治疗组患儿血浆8-iso-PGF2α水平仍高于同期正常新生儿水平,差异具有高度统计学意义(P<0.01);氨溴索治疗组患儿血浆8-iso-PGF2α水平下降,接近于同期正常新生儿水平。结论 HIE患儿存在脂质过氧化作用,盐酸氨溴索具有抗氧化作用,可使HIE患儿体内8-iso-PG2α水平下降,有必要加用。更多还原

【Abstract】 Objective To determinate plasma 8-iso-prostaglandin F2α(8-iso-PGF2α)levels,and to investigate the clinical effect of ambroxol on lowering 8-iso-PGF2αconcentration in the neonates with hypoxic-ischemic encephalopathy(HIE).Methods Fifty one moderate HIE full-term neonates were recruited as group routine therapy(26 cases)and group ambroxol therapy[25 cases,30 mg/(kg.d)].Therapeutic intervention started 1 day after birth,3 days for one period of treatment.In addition,25 full-term neonates without HIE were serve as control.Plasma samples from HIE and normal neonates were collected on day 1 and 3 after birth.Plasma 8-iso-PGF2αlevels were determined by EIA assay.Results(1)Before intervention,plasma 8-iso-PGF2αlevels in group ambroxol and group routine were obviously higher than level of normal newborn infants.The differences were statistically significant(P<0.01).(2)7 days after treatment,group routine were obviously higher than normal level of newborn infants,the differences were statistically significant(P<0.01),and plasma 8-iso-PGF2αlevel closed to normal level of newborn babies in group ambroxol.Conclusion Lipid peroxidation exists,and high-dose ambroxol as antioxidant can markedly decrease 8-iso-PG2αlevel in HIE neonates.It is necessary for ambroxol in HIE therapeutic regime.更多还原