【摘要】 目的探讨肾上腺髓质素(AM)及其受体——降钙素受体样受体(CRLR)在子宫内膜腺癌组织中的表达与子宫内膜腺癌微血管密度(MVD)的相关性。方法免疫组化法检测2006年1月至2010年1月中国医科大学附属第一医院以及解放军202医院收治的15例子宫内膜单纯性增生、21例子宫内膜不典型增生、50例子宫内膜腺癌组织中AM及CRLR蛋白表达;利用CD34免疫组化法检测组织内MVD,并研究与临床病理学参数的关系。结果 AM在子宫内膜腺癌中的表达高于单纯性增生组织(P<0.05);CRLR蛋白在子宫内膜腺癌中的表达高于单纯性增生、不典型增生组织(P<0.05);在子宫内膜腺癌中,AM与CRLR的蛋白表达呈正相关(r=0.399,P=0.004),AM与CRLR的表达均与肿瘤的MVD呈正相关(P<0.05)。结论 AM及其受体CRLR与子宫内膜腺癌的发生有关,并且参与肿瘤的血管发生。更多还原

【Abstract】 Objective To investigate the AM and its receptor CRLR expression in endometrial carcinoma and compare with clinicopathological parameters. Methods The expression levels of AM and CRLR in 15 cases of normal proliferative endometrium,21 cases of atypical endometrial hyperplasia and 50 cases of endometrial carcinoma was measured by immunohistochemical analysis. The expression level of MVD was measured by CD34 staining by immunohistochemical staining. We further compared the expression of AM and CRLR in different tissues and investigated relationship between the expressions and the clinicopathological parameters. Results The expression of AM in endometrial carcinoma were higher than normal proliferative endometrium; the expression of CRLR in endometrial carcinoma were higher than normal proliferative endometrium and atypical endometrial hyperplasia. In endometrial cancers,AM expression was significantly related to CRLR expression,both AM and CRLR expressions were significantly related to MVD. Conclusion AM may play important roles in endometrial carcinoma carcinogenesis and angiogenesis via activating CRLR receptor and may be used as anti-angiogenesis agents.更多还原