【摘要】 目的探讨新疆地区汉族、维族帕金森病(PD)患病的危险因素。方法选取2008年～2010年新疆部分三级医院确诊的PD患者262例,汉族159例,维族103例,同时选取健康对照组做病例对照研究。结果条件logistic回归分析显示,汉族非喝茶者患PD的危险性是喝茶者的4.7倍[Exp(B)分别为0.21],非吸烟者患PD的危险性是吸烟者的2.8倍[Exp(B)=0.35];农药接触史者患PD的危险性是非农药接触史者的1.42倍,重大精神创伤史者患PD的危险性是非重大精神创伤史者的16.16倍。维族非喝茶者患PD的危险性是喝茶者2.1倍[Exp(B)=0.47];农药接触史者患PD的危险性是非农药接触史者4.62倍。结论喝茶是PD的保护因素,农药接触史是PD的危险因素。汉族配对研究中,吸烟、饮用井水、高血压病史具有保护作用,重大精神创伤史是PD的危险因素。更多还原

【Abstract】 Objective To explore the risk factors for Parkinson’s disease(PD) in the Hans and Uygurs in Xinjiang.Methods Two case-control studies including 262 pairs of cases matched on gender,age and nationality were recruited,based on hospital diagnosis,from 2008 to 2010.Results In the Hans,the risk was one-fifth,compared with people who do not drink tea [Exp(B)=0.21].The risk of smokers for PD was one third,compared with non-smokers[Exp(B)=0.35].The risk was more times to people for PD,with History of exposured to pesticides and experienced negative life events.In the Uygurs,the risk of people drinking tea for PD was one-fifth,compared with people who do not drinking tea[Exp(B)=0.47].The risk was 4.62 times to people with History of exposured to pesticides.Conclusion Risk factors for PD in different ethnic may be different.更多还原