【摘要】 目的探讨脂蛋白相关磷脂酶A2基因A379V基因多态性对冠心病患者预后的影响。方法采用单荧光标记探针技术检测261例冠心病患者脂蛋白相关磷脂酶A2基因(LP-PLA2)A379V基因多态性,按基因型对患者分组,观察冠脉造影术后1年间死亡、非致死性心肌梗死、急性血运重建和心绞痛复发等严重不良心血管事件的发生情况。结果两组患者急性心肌梗死、急诊血运重建术的发生率没有明显统计学差异(P>0.05),但V等位基因携带者心绞痛复发率、死亡率高于AA基因型组,有统计学差异(P<0.05)。V等位基因携带者一年累计生存率高于AA基因型患者(HR=2.883,95%CI:1.049-7.920,P=0.040)。结论 LP-PLA2基因A379V多态性是中国汉族人群冠心病临床预后的主要影响因素之一。更多还原

【Abstract】 Objective To investigate the effect of gene polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) A379V on the prognosis of coronary heart disease (CHD). Methods The gene polymorphism of Lp-PLA2 A379V was determined by single-labeled probe technique in 261 CHD patients who received coronary angiography (CAG). The patients were divided into two groups according to A379V genotypes. The prognoses of both groups were evaluated based on occurrences of death, nonfatal myocardial infarction (MI), and urgent coronary revascularization as well as angina recurrence one year after CAG. Results There were no significant differences in the occurrence rates of acute MI and urgent coronary revascularization between the two groups (P>0.05). The V allele carriers showed significantly higher angina recurrence rate and death rate than AA allele carriers (P<0.05). In addition, the V allele carriers had significantly higher one-year survival rate than AA allele carriers (HR = 2.883, 95% CI=1.049-7.920; P=0.040). Conclusion The gene polymorphism of Lp-PLA2 A379V is the main influential factor for the prognosis of CHD in Han population in China.更多还原